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The Interventions Testing Program

The Interventions Testing Program (ITP) is a mouse lifespan study programme of the United States National Institute on Aging. RNAWiki reads the cohort workbooks published through the Jackson Laboratory Mouse Phenome Database, and prints the rows they contain.

A cohort is named for the year its mice were bred, so C2015 is the cohort bred in 2015. The table gives the source’s own name for each study arm, the dose exactly as the source prints it with its unit, the number of mice recorded for each sex, and the age at which the arm started. Where the only recorded dose is a number with no unit, the cell says so instead of printing the number: a concentration without its unit is not a dose. No median, percentage change or survival figure is calculated from these rows on this page. 51 compounds in the corpus have at least one recorded cohort.

Mouse cohorts

Mouse cohorts recorded by the Interventions Testing Program, one row per compound and cohort
CompoundCohortStudy armDose as the source prints itAge at start (months)Female miceMale mice
1,3-BUTANEDIOLC2017(R/S)-1,3-butanediol100,000 ppm6.0136156
2,4-DinitrophenolC20202,4-dinitrophenol3 ppm132150
AcarboseC2009acarbose1000 ppm4.0136156
AcarboseC2012acarbose1000 ppm16.0136156
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0152168
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0140165
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0144162
AcarboseC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm16.0136156
AcarboseC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm9.0136156
AcarboseC2009acarbose1000 ppm4.0136156
AcarboseC2012acarbose1000 ppm16.0136156
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0152168
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0140165
AcarboseC2013acarbose400 (lo), 1000 (mid), and 2500 (hi) ppm8.0144162
AcarboseC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm16.0136156
AcarboseC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm9.0136156
AlfatradiolC200917-a-estradiol4.8 ppm10.0136156
AlfatradiolC201117-a-estradiol14.4 ppm10136156
AlfatradiolC201617-a-estradiol14.4 ppm16.0156
AlfatradiolC201617-a-estradiol14.4 ppm20.0159
Alpha KetoglutarateC2020a-Ketoglutarate20,000 ppm132153
AlvespimycinC201517-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride30 ppm6136156
ASAC2004aspirin21 ppm4.0144180
ASAC2014aspirin60 and 200 ppm11.0136156
ASAC2014aspirin60 and 200 ppm11.0136156
ASTAXANTHINC2019astaxanthin4000 ppm136156
ASTAXANTHIN, (R,R)-C2019astaxanthin4000 ppm136156
CAFFEIC ACID PHENETHYL ESTERC2005caffeic acid phenethyl ester30 (lo) and 300 (hi) ppm4.0148183
CAFFEIC ACID PHENETHYL ESTERC2005caffeic acid phenethyl ester30 (lo) and 300 (hi) ppm4.0144180
Camellia Sinensis LeafC2007green tea extract2000 ppm4.0130153
Canagliflozin AnhydrousC2016canagliflozin180 ppm7.0136156
Canagliflozin AnhydrousC2020canagliflozin180 ppm92102
Canagliflozin AnhydrousC2020canagliflozin180 ppm4460
Candesartan CilexetilC2016candesartan cilexetil30 ppm8.0136156
CaptoprilC2017captopril180 ppm5.0136156
ColforsinC2021Forskolin5 ppm7.0144156
CurcuminC2007curcumin2000 ppm4.0132158
DICHLOROACETIC ACIDC2021Dichloroacetate30 ppm7.0144156
DIMETHYL FUMARATEC2019dimethyl fumarate120 ppm136156
DIMETHYL FUMARATEC2019dimethyl fumarate120 ppm135156
EnalaprilC2005enalapril120 ppm4.0144180
(-)-EPICATECHINC2021Epicatechin60 ppm7.0144153
FisetinC2018fisetin600 ppm144156
FisetinC2018fisetin600 ppm144159
Fish OilC2010fish oil15,000 (lo) and 50,000 (hi) ppm9.0136156
Fish OilC2010fish oil15,000 (lo) and 50,000 (hi) ppm9.0136156
GlycineC2014glycine80,000 ppm9.0136156
HalofuginoneC2021Halofuginone0.6 ppm7.0144159
HalofuginoneC2021Halofuginone0.6 ppm7.0144159
HydralazineC2020Hydralazine30 ppm132153
HydralazineC2020Hydralazine30 ppm132153
InulinC2014inulin600 ppm11.0136156
LeucineC2017L-Leucine40,000 ppm5.0136156
Leucine 1-C-11C2017L-Leucine40,000 ppm5.0136156
MeclozineC2019meclizine800 ppm136155
MetforminC2011metformin1000 ppm9144162
MetforminC2011metformin plus rapamycinMet: 1000 ppm and Rapa: 14 ppm9144162
Methylene Blue CationC2009methylene blue28 ppm4.0136156
MinocyclineC2015minocycline300 ppm6136156
MITOGLITAZONEC2021Mitoglitazone300 ppm7.0144153
MITOQUINONE CATIONC2015MitoQ100 ppm7136156
Mycophenolic acidC2019mycophenolic acid6.7 ppm136156
NebivololC2020Nebivolol60 ppm132150
NebivololC2020Nebivolol60 ppm132150
NICOTINAMIDE RIBOSIDEC2016nicotinamide riboside1000 ppm8.0136156
NORDIHYDROGUAIARETIC ACIDC2004nordihydroguaiaretic acid2500 ppm9.0149180
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acid800 (lo), 2500 (mid), and 5000 (hi) ppm6.0136156
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acid800 (lo), 2500 (mid), and 5000 (hi) ppm6.0156
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acid800 (lo), 2500 (mid), and 5000 (hi) ppm6.0156
OmpenaclidC2015b-guanidinopropionic acid3300 ppm6136156
OXALOACETATEC2007oxaloacetic acid2200 ppm4.0134153
ResveratrolC2006resveratrol300 (lo) and 1200 (hi) ppm12.0144168
ResveratrolC2006resveratrol300 (lo) and 1200 (hi) ppm12.0144165
ResveratrolC2007resveratrol300 ppm4.0131153
SimvastatinC2006simvastatin12 (lo) and 120 (hi) ppm10.0144168
SimvastatinC2006simvastatin12 (lo) and 120 (hi) ppm10.0143167
SinecatechinsC2007green tea extract2000 ppm4.0130153
SirolimusC2005rapamycin14 ppm20.0144177
SirolimusC2006rapamycin14 ppm9.0144171
SirolimusC2009rapamycin4.7 (lo), 14 (mid), and 42 (hi) ppm9.0136156
SirolimusC2009rapamycin4.7 (lo), 14 (mid), and 42 (hi) ppm9.0136156
SirolimusC2009rapamycin4.7 (lo), 14 (mid), and 42 (hi) ppm9.0136156
SirolimusC2011metformin plus rapamycinMet: 1000 ppm and Rapa: 14 ppm9144162
SirolimusC2015rapamycin42 ppm20136156
SirolimusC2015rapamycin42 ppm20 but every other136159
SirolimusC2015rapamycin42 ppm20 thru 23136153
SirolimusC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm16.0136156
SirolimusC2017rapamycin plus acarboseRapa: 14.7 ppm and ACA: 1000 ppm9.0136156
Sodium ThiosulfateC2020Sodium thiosulfate10,000 ppm132153
SulindacC2017sulindac5 ppm5.0136156
Ursodeoxycholic acidC2011ursodeoxycholic acid5000 ppm5136156
Ursolic AcidC2013ursolic acid2000 ppm10.0148168
Show the workbook rows
The identifiers each cohort row carries in the source workbook
CompoundCohortAgent as the workbook writes itArm codeWorkbook
1,3-BUTANEDIOLC2017(R/S)-1,3-butanediolBDITP_C2017_Lifespan.xlsx
2,4-DinitrophenolC20202,4-dinitrophenolDNPITP_C2020_Lifespan.xlsx
AcarboseC2009acarboseACAITP_C2009_Lifespan.xlsx
AcarboseC2012acarboseACAITP_C2012_Lifespan.xlsx
AcarboseC2013acarboseACA_hiITP_C2013_Lifespan.xlsx
AcarboseC2013acarboseACA_loITP_C2013_Lifespan.xlsx
AcarboseC2013acarboseACA_midITP_C2013_Lifespan.xlsx
AcarboseC2017rapamycin plus acarboseRaAc_16ITP_C2017_Lifespan.xlsx
AcarboseC2017rapamycin plus acarboseRaAc_9ITP_C2017_Lifespan.xlsx
AcarboseC2009acarboseACAITP_C2009_Lifespan.xlsx
AcarboseC2012acarboseACAITP_C2012_Lifespan.xlsx
AcarboseC2013acarboseACA_hiITP_C2013_Lifespan.xlsx
AcarboseC2013acarboseACA_loITP_C2013_Lifespan.xlsx
AcarboseC2013acarboseACA_midITP_C2013_Lifespan.xlsx
AcarboseC2017rapamycin plus acarboseRaAc_16ITP_C2017_Lifespan.xlsx
AcarboseC2017rapamycin plus acarboseRaAc_9ITP_C2017_Lifespan.xlsx
AlfatradiolC200917-a-estradiol17aE2ITP_C2009_Lifespan.xlsx
AlfatradiolC201117-a-estradiol17aE2ITP_C2011_Lifespan.xlsx
AlfatradiolC201617-a-estradiol17aE2_16mITP_C2016_Lifespan.xlsx
AlfatradiolC201617-a-estradiol17aE2_20mITP_C2016_Lifespan.xlsx
Alpha KetoglutarateC2020a-KetoglutarateAKG_18ITP_C2020_Lifespan.xlsx
AlvespimycinC201517-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochlorideDMAGITP_C2015_Lifespan.xlsx
ASAC2004aspirinAspirinITP_C2004_Lifespan.xlsx
ASAC2014aspirinAsp_200ITP_C2014_Lifespan.xlsx
ASAC2014aspirinAsp_60ITP_C2014_Lifespan.xlsx
ASTAXANTHINC2019astaxanthinAstaITP_C2019_Lifespan.xlsx
ASTAXANTHIN, (R,R)-C2019astaxanthinAstaITP_C2019_Lifespan.xlsx
CAFFEIC ACID PHENETHYL ESTERC2005caffeic acid phenethyl esterCAPE_hiITP_C2005_Lifespan.xlsx
CAFFEIC ACID PHENETHYL ESTERC2005caffeic acid phenethyl esterCAPE_loITP_C2005_Lifespan.xlsx
Camellia Sinensis LeafC2007green tea extractGTEITP_C2007_Lifespan.xlsx
Canagliflozin AnhydrousC2016canagliflozinCanaITP_C2016_Lifespan.xlsx
Canagliflozin AnhydrousC2020canagliflozinCana_16ITP_C2020_Lifespan.xlsx
Canagliflozin AnhydrousC2020canagliflozinCana_6ITP_C2020_Lifespan.xlsx
Candesartan CilexetilC2016candesartan cilexetilCCITP_C2016_Lifespan.xlsx
CaptoprilC2017captoprilCaptITP_C2017_Lifespan.xlsx
ColforsinC2021ForskolinForITP_C2021_Lifespan.xlsx
CurcuminC2007curcuminCurITP_C2007_Lifespan.xlsx
DICHLOROACETIC ACIDC2021DichloroacetateDCAITP_C2021_Lifespan.xlsx
DIMETHYL FUMARATEC2019dimethyl fumarateDMF_16ITP_C2019_Lifespan.xlsx
DIMETHYL FUMARATEC2019dimethyl fumarateDMF_9ITP_C2019_Lifespan.xlsx
EnalaprilC2005enalaprilEnalITP_C2005_Lifespan.xlsx
(-)-EPICATECHINC2021EpicatechinEpiITP_C2021_Lifespan.xlsx
FisetinC2018fisetinFis_CycITP_C2018_Lifespan.xlsx
FisetinC2018fisetinFis_OnITP_C2018_Lifespan.xlsx
Fish OilC2010fish oilFO_hiITP_C2010_Lifespan.xlsx
Fish OilC2010fish oilFO_loITP_C2010_Lifespan.xlsx
GlycineC2014glycineGlyITP_C2014_Lifespan.xlsx
HalofuginoneC2021HalofuginoneHalITP_C2021_Lifespan.xlsx
HalofuginoneC2021HalofuginoneHalITP_C2021_Lifespan.xlsx
HydralazineC2020HydralazineHYD_16ITP_C2020_Lifespan.xlsx
HydralazineC2020HydralazineHYD_6ITP_C2020_Lifespan.xlsx
InulinC2014inulinInuITP_C2014_Lifespan.xlsx
LeucineC2017L-LeucineLeuITP_C2017_Lifespan.xlsx
Leucine 1-C-11C2017L-LeucineLeuITP_C2017_Lifespan.xlsx
MeclozineC2019meclizineMecITP_C2019_Lifespan.xlsx
MetforminC2011metforminMetITP_C2011_Lifespan.xlsx
MetforminC2011metformin plus rapamycinMetRapaITP_C2011_Lifespan.xlsx
Methylene Blue CationC2009methylene blueMBITP_C2009_Lifespan.xlsx
MinocyclineC2015minocyclineMinITP_C2015_Lifespan.xlsx
MITOGLITAZONEC2021MitoglitazoneM160ITP_C2021_Lifespan.xlsx
MITOQUINONE CATIONC2015MitoQMitoQITP_C2015_Lifespan.xlsx
Mycophenolic acidC2019mycophenolic acidMPAITP_C2019_Lifespan.xlsx
NebivololC2020NebivololNEBIITP_C2020_Lifespan.xlsx
NebivololC2020NebivololNEBIITP_C2020_Lifespan.xlsx
NICOTINAMIDE RIBOSIDEC2016nicotinamide ribosideNRITP_C2016_Lifespan.xlsx
NORDIHYDROGUAIARETIC ACIDC2004nordihydroguaiaretic acidNDGAITP_C2004_Lifespan.xlsx
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acidND_hiITP_C2010_Lifespan.xlsx
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acidND_loITP_C2010_Lifespan.xlsx
NORDIHYDROGUAIARETIC ACIDC2010nordihydroguaiaretic acidND_midITP_C2010_Lifespan.xlsx
OmpenaclidC2015b-guanidinopropionic acidbGPAITP_C2015_Lifespan.xlsx
OXALOACETATEC2007oxaloacetic acidOAAITP_C2007_Lifespan.xlsx
ResveratrolC2006resveratrolRes_hiITP_C2006_Lifespan.xlsx
ResveratrolC2006resveratrolRes_loITP_C2006_Lifespan.xlsx
ResveratrolC2007resveratrolResITP_C2007_Lifespan.xlsx
SimvastatinC2006simvastatinSim_hiITP_C2006_Lifespan.xlsx
SimvastatinC2006simvastatinSim_loITP_C2006_Lifespan.xlsx
SinecatechinsC2007green tea extractGTEITP_C2007_Lifespan.xlsx
SirolimusC2005rapamycinRapaITP_C2005_Lifespan.xlsx
SirolimusC2006rapamycinRapaITP_C2006_Lifespan.xlsx
SirolimusC2009rapamycinRapa_hiITP_C2009_Lifespan.xlsx
SirolimusC2009rapamycinRapa_loITP_C2009_Lifespan.xlsx
SirolimusC2009rapamycinRapa_midITP_C2009_Lifespan.xlsx
SirolimusC2011metformin plus rapamycinMetRapaITP_C2011_Lifespan.xlsx
SirolimusC2015rapamycinrapa_hi_continuousITP_C2015_Lifespan.xlsx
SirolimusC2015rapamycinrapa_hi_cycleITP_C2015_Lifespan.xlsx
SirolimusC2015rapamycinrapa_hi_start_stopITP_C2015_Lifespan.xlsx
SirolimusC2017rapamycin plus acarboseRaAc_16ITP_C2017_Lifespan.xlsx
SirolimusC2017rapamycin plus acarboseRaAc_9ITP_C2017_Lifespan.xlsx
Sodium ThiosulfateC2020Sodium thiosulfateTHIOITP_C2020_Lifespan.xlsx
SulindacC2017sulindacSulITP_C2017_Lifespan.xlsx
Ursodeoxycholic acidC2011ursodeoxycholic acidUDCAITP_C2011_Lifespan.xlsx
Ursolic AcidC2013ursolic acidUAITP_C2013_Lifespan.xlsx

Reported outcomes

Each sentence below is quoted from the publication record named with it, without change. A paper that names several compounds is quoted once and linked to each of them.

Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

Organism
mouse
PubMed identifier (PMID)
41843349
Published
2026
Record read
2026-03-17
  • Notably, astaxanthin, mitoglitazone, and meclizine-previously associated with lifespan extension in the ITP-showed no benefit when administered at different doses or starting at later ages.
  • In females, astaxanthin, late-start mitoglitazone, and pioglitazone were associated with significantly reduced lifespan when pooling the data from all three sites.

Recorded forASTAXANTHINASTAXANTHIN, (R,R)-MeclozineMITOGLITAZONE

End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin.

Organism
mouse
PubMed identifier (PMID)
40601216
Published
2026
Record read
2025-07-02
  • Canagliflozin (Cana) started at 16 months of age and 16-hydroxy-estradiol (OH_Est) started at 12 months each led to significant increases in lifespan in male UM-HET3 mice but significant decreases in female lifespan.

Recorded forCanagliflozin Anhydrous

Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

Organism
mouse
PubMed identifier (PMID)
40973907
Published
2026
Record read
2025-09-19
  • Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT).

Recorded for(-)-EPICATECHINHalofuginoneHalofuginoneMITOGLITAZONE

Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice.

Organism
mouse
PubMed identifier (PMID)
41863332
Published
2026
Record read
2026-05-01
  • Interventions Testing Program identified rapamycin as a robust lifespan-extending agent at multiple testing sites and in both sexes, with particularly strong effects in females, making it a leading candidate in aging research.

Recorded forSirolimus

The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride.

Organism
mouse
PubMed identifier (PMID)
38630424
Published
2024
Record read
2024-04-17
  • The Gehan test identified 5 additional compounds, metformin, enalapril, 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG), caffeic acid phenethyl ester (CAPE), and green tea extract (GTE), which significantly increased survival but were previously missed by the log-rank test.

Recorded forCAFFEIC ACID PHENETHYL ESTEREnalaprilMetformin

The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride

Organism
mouse
Europe PMC record
PPR810839
Published
2024
Record read
2024-02-21
  • The Gehan test identified 5 additional compounds, metformin, enalapril, 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG), caffeic acid phenethyl ester (CAPE), and green tea extract (GTE), which significantly increased survival but were previously missed by the log-rank test.

Recorded forCAFFEIC ACID PHENETHYL ESTEREnalaprilMetformin

Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice.

Organism
mouse
PubMed identifier (PMID)
35707855
Published
2022
Record read
2022-06-15
  • Recently, the Interventions Testing Program demonstrated that the anti-diabetes drug, Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor, led to lower fasting glucose and improved glucose tolerance in both sexes, but extended median lifespan by 14% in male mice only.

Recorded forCanagliflozin Anhydrous

Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice

Organism
mouse
Europe PMC record
PPR448112
Published
2022
Record read
2022-01-28
  • Recently, the Interventions Testing Program (ITP) demonstrated that the anti-diabetes drug, Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor (SGLT2i), led to lower fasting glucose and improved glucose tolerance in both sexes, but extended median lifespan by 14% only in male mice.

Recorded forCanagliflozin Anhydrous

Canagliflozin increases adenoma burden in female APC Min/+ mice

Organism
mouse
Europe PMC record
PPR303955
Published
2021
Record read
2021-03-28
  • A recent study by NIA’s Interventions Testing Program (ITP) showed that canagliflozin treatment extends lifespan in male mice.
  • Our results suggest that canagliflozin exacerbates adenomatosis in the APC Min/+ model via complex, cell-non-autonomous mechanisms, and hint that sex differences in incretin responses may underlie differential effects of this drug on lifespan.

Recorded forCanagliflozin Anhydrous

Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.

Organism
mouse
PubMed identifier (PMID)
31353414
Published
2020
Record read
2020-01-01
  • The National Institute on Aging (NIA)-sponsored Interventions Testing Program (ITP) has identified a number of dietary drug interventions that significantly extend life span, including rapamycin, acarbose, and 17-α estradiol.
  • Additionally, HET3 mice exhibit a spectrum of age-associated changes in the gWAT, but acarbose and 17-α estradiol do not strongly alter these phenotypes-suggesting that acarbose and 17- α estradiol may not influence life span through mechanisms involving adipose tissue inflammation.

Recorded forAcarboseAcarboseSirolimus

Canagliflozin extends life span in genetically heterogeneous male but not female mice.

Organism
mouse
PubMed identifier (PMID)
32990681
Published
2020
Record read
2020-11-05
  • Therefore, the life span benefit of Cana is likely to reflect blunting of peak glucose levels, because similar longevity effects are seen in male mice given acarbose, a diabetes drug that blocks glucose surges through a distinct mechanism, i.e., slowing breakdown of carbohydrate in the intestine.

Recorded forAcarboseAcarbose

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

Organism
mouse
Europe PMC record
PPR167670
Published
2020
Record read
2020-05-26
  • The lifespan benefit of Cana is likely to reflect blunting of peak glucose levels, because similar longevity effects are seen in mice given acarbose, a diabetes drug that blocks glucose surges through a distinct mechanism, i.e. slowing breakdown of carbohydrate in the intestine.

Recorded forAcarboseAcarbose

Naturally occurring osteoarthritis in male mice with an extended lifespan.

Organism
mouse
PubMed identifier (PMID)
31530037
Published
2020
Record read
2019-09-18
  • Aim: The purpose of this study was to evaluate whether pharmacologic treatments or genotypes shown to prolong murine lifespan ameliorate the severity of age-associated osteoarthritis.Materials and Methods: Male UM-HET3 mice were fed diets containing 17-α-estradiol, acarbose, nordihydroguaiaretic acid, or control diet per the National Institute on Aging Interventions Testing Program (ITP) protocol.

Recorded forAcarboseAcarboseNORDIHYDROGUAIARETIC ACID

Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging.

Organism
mouse
PubMed identifier (PMID)
31187283
Published
2019
Record read
2019-06-11
  • Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane administration increase longevity and stress resistance in model organisms such as yeasts, nematodes, flies and mice.

Recorded forCurcuminResveratrolSirolimus

Glycine supplementation extends lifespan of male and female mice.

Organism
mouse
PubMed identifier (PMID)
30916479
Published
2019
Record read
2019-03-27
  • Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats.
  • We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program.
  • Elevated glycine led to a small (4%-6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001).
  • Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively.
  • Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late-life diseases.

Recorded forGlycine

DIFFERENTIAL EFFECTS OF ITP LIFESPAN EXTENSION DRUGS ON ADIPOSE TISSUE INFLAMMATION IN AGING

Organism
mouse
Europe PMC record
PMC6239373
Published
2018
Record read
2018-11-01
  • Abstract The National Institute on Aging-sponsored Interventions Testing Program (ITP) has identified a number of dietary drug interventions that significantly extend median lifespan, including rapamycin, acarbose, and 17-α estradiol.
  • Our data also suggest that acarbose and 17-α estradiol may not influence lifespan through mechanisms involving adipose tissue inflammation.
  • Our data suggest that rapamycin may achieve lifespan extension in part through adipose tissue inflammation.

Recorded forAcarboseAcarboseSirolimus

Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice.

Organism
mouse
PubMed identifier (PMID)
29579736
Published
2018
Record read
2018-03-01
  • The use of rapamycin to extend lifespan and delay age-related disease in mice is well-established despite its potential to impair glucose metabolism which is driven partially due to increased hepatic gluconeogenesis.
  • Together, our data provide compelling evidence that the pro-longevity effects of rapamycin can be uncoupled from its detrimental effects on metabolism through combined therapeutic approaches.

Recorded forSirolimus

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Organism
mouse
PubMed identifier (PMID)
27312235
Published
2016
Record read
2016-06-16
  • The α-glucosidase inhibitor, acarbose, at a concentration previously tested (1000 ppm), significantly increased median longevity in males and 90th percentile lifespan in both sexes, even when treatment was started at 16 months.
  • Neither fish oil nor UDCA extended lifespan.
  • Metformin alone, at a dose of 0.1% in the diet, did not significantly extend lifespan.
  • Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit, based on historical comparison with earlier studies of rapamycin given alone.

Recorded forAcarboseAcarboseFish OilMetforminSirolimus

Fish oil supplements, longevity and aging.

Organism
mouse
PubMed identifier (PMID)
27564420
Published
2016
Record read
2016-08-01
  • Initial results from short-lived mouse strains showed that fish oil can increase lifespan, affecting pathways like inflammation and oxidation thought to be involved in the regulation of aging.
  • Using a large cohort of genetically heterogeneous mice in three sites, part of the Interventions Testing Program of the NIA, Strong et al. show that fish oil supplementation at either low or high dosages has no effect on the lifespan of male or female mice.
  • Although it is still possible that fish oil supplementation has health benefits for specific age-related diseases, it does not appear to slow aging or have longevity benefits.

Recorded forFish Oil

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Organism
mouse
PubMed identifier (PMID)
22451473
Published
2013
Record read
2012-03-26
  • We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice.

Recorded forCurcuminResveratrol

Where these rows come from

Source
Jackson Laboratory Mouse Phenome Database, ITP project
Workbooks read
ITP_C2004_Lifespan.xlsx, ITP_C2005_Lifespan.xlsx, ITP_C2006_Lifespan.xlsx, ITP_C2007_Lifespan.xlsx, ITP_C2009_Lifespan.xlsx, ITP_C2010_Lifespan.xlsx, ITP_C2011_Lifespan.xlsx, ITP_C2012_Lifespan.xlsx, ITP_C2013_Lifespan.xlsx, ITP_C2014_Lifespan.xlsx, ITP_C2015_Lifespan.xlsx, ITP_C2016_Lifespan.xlsx, ITP_C2017_Lifespan.xlsx, ITP_C2018_Lifespan.xlsx, ITP_C2019_Lifespan.xlsx, ITP_C2020_Lifespan.xlsx, ITP_C2021_Lifespan.xlsx
Dose column read from
JAX MPD ITP project page cohort legend, dose column
Last verified
2026-09-04
Reuse
Contributors to the Mouse Phenome Database waive copyright in the deposited data. Quoted sentences stay with their publisher.

cohort rows are the workbook's own printed values; no median, percent change or survival statistic is derived from the per-animal data

Definitions