Its recorded molecular formula is C15H10O6, weighing 286.24.
PubChem record · 5281614 · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Protein
A protein is a folded chain your body builds to do a specific job.
A picture of it, and where the picture fails
A protein is like a tool bent into one shape for one task.
Where that stops being true. A tool keeps its shape. A protein can change shape and stop working.
What people get wrong. Protein in food and a protein in the body are related but not the same thing.
A polymer of amino acids folded into a defined structure that determines its function.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 15 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Endurance
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer2 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Endurance
6 minute walk distance; six minute walk distance
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
2 registered performance measure of this kind.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Difference in the composite cardiovascular, respiratory, and renal sequential organ failure assessment (CRR-SOFA)
✗ The study did not show it
Who was studied
NCT05758246
How many people
220
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in 6 minute walk distance (6MWD)
✗ The study did not show it
Who was studied
NCT06113016
How many people
164
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in retinal amyloid burden, as measured by retinal amyloid scan.
✗ The study did not show it
Who was studied
NCT02741804
How many people
150
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in walking speed
✗ The study did not show it
Who was studied
NCT04733534
How many people
110
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Incidence of Treatment-Emergent Adverse Events
✗ The study did not show it
Who was studied
NCT04815902
How many people
100
Study design
Phase 1/Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.3 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.3 registered measures of this kind.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
No registered study measured anything of this kind.
Meaningful
Things that change how a life goes, not only a number.
walking speed
6 minute walk distance
six minute walk distance
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (12)
overall gulf war illness disease severity
c terminal telopeptide of type i collagen
serious adverse events
oxygenation status
senescent cell abundance in blood
incidence of treatment emergent adverse events
adverse events
completion of 3 cycles
turnaround time for scan and marker data
forced vital capacity
forced expiratory volume in 1 second
fev1/fvc
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
55 marketed supplement labels list this ingredient, classed as non-nutrient/non-botanical.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
How this medicine reached us — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Fisetin's largest trial (164 people) and its longest (9.7 years) measure?
164 people in Fisetin's largest registered study, 9.7 years in its longest registered window, measuring Senescent cell abundance in blood (p16INK4A). ClinicalTrials.gov · 2026-09-01
22 phase2, 5 phase1, 2 na, 2 phase3, 1 early phase1; NCT03430037; 2027-11. Last human test completed 2026, NCT07279714.
Interpretation These counts include studies where Fisetin was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
22
phase1
5
na
2
phase3
2
early phase1
1
Last recorded human testNCT07279714
2026-07-21
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Fisetin shown lifespan?
"Due to lack of funding"; 4 of 25 registered studies
Show the evidence
Trial
NCT03325322
suspended; "Due to lack of funding"
NCT04537299
terminated; "The DSMB and NIA determined the study should be stopped due to futility."
NCT05482672
withdrawn; "Lack of funding"
NCT05505747
withdrawn; "Funding not awarded"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Mouse studies of Fisetin used 600 ppm — over how long?
Mouse studies of Fisetin used "600 ppm". jax-mpd-itp · 2026-09-04
Show the evidence
mouse
fisetin C2018
600 ppm
fisetin C2018
600 ppm
recorded 2026-09-04 · last checked 2026-09-04
Q5
Did Fisetin move epigenetic age, and by how much?
epigenetic age: "Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging." Europe PMC · epigenetic clock search · 2024-02-22
1 recorded sentence; 2024; biomarker
Show the evidence
epigenetic agePMID 38393697
2024; "Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging."
recorded 2024-02-22 · last checked 2026-09-04
Q6
More Fisetin was worse in human: at what point?
Hormetic in human: "The present paper provides the first integrated assessment of the capacity of the flavonol, fisetin, to induce hormetic dose responses." Europe PMC · dose-response search · 2025-04-24
4 recorded sentences naming Fisetin; hormetic
Show the evidence
hormetic
PMID 40208387
"The present paper provides the first integrated assessment of the capacity of the flavonol, fisetin, to induce hormetic dose responses."
PMID 40208387
"Fisetin was shown to induce hormetic dose responses in cellular and in vivo animal model systems affecting a broad range of endpoints of potential therapeutic and public health significance across the entire lifespan."
PMID 40208387
"Fisetin was effective in slowing aging processes, acting as a senolytic agent in multiple organ systems, in an hormetic fashion."
PMID 40287100
"While the hormetic effects of kaempferol are biologically diverse, there has been a strong focus on age-related endpoints affecting numerous organ systems and endpoints, indicating that kaempferol is a senolytic agent, showing similar properties as quercetin and fisetin."
recorded 2025-04-24 · last checked 2026-09-04
Q7
Could one person measure Fisetin's effect on overall gulf war illness disease severity?
Overall gulf war illness disease severity: measured in Fisetin's trials.
Interpretation overall gulf war illness disease severity is the recorded endpoint.
Show the evidence
biomarkers
overall gulf war illness disease severity; 2026-09-01
c terminal telopeptide of type i collagen; 2026-09-01
serious adverse events; 2026-09-01
oxygenation status; 2026-09-01
walking speed; 2026-09-01
senescent cell abundance in blood; 2026-09-01
9 more recorded rows
biomarkers
incidence of treatment emergent adverse events; 2026-09-01
biomarkers
6 minute walk distance; 2026-09-01
biomarkers
six minute walk distance; 2026-09-01
biomarkers
adverse events; 2026-09-01
biomarkers
completion of 3 cycles; 2026-09-01
biomarkers
turnaround time for scan and marker data; 2026-09-01
biomarkers
forced vital capacity; 2026-09-01
biomarkers
forced expiratory volume in 1 second; 2026-09-01
biomarkers
fev1/fvc; 2026-09-01
human trials at or under30
7
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT05482672; PHASE2/PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q8
Which of 6 minute walk distance, adverse events and c terminal telopeptide of type i collagen did Fisetin's trials measure?
6 minute walk distance, adverse events and c terminal telopeptide of type i collagen lead 15 outcome terms across Fisetin's trials. ClinicalTrials.gov · 2026-09-01
oxygenation status, walking speed, senescent cell abundance in blood, incidence of treatment emergent adverse events, 6 minute walk distance and six minute walk distance follow.
Show the evidence
overall gulf war illness disease severity
1
c terminal telopeptide of type i collagen
1
serious adverse events
1
oxygenation status
1
walking speed
1
senescent cell abundance in blood
1
9 more recorded rows
incidence of treatment emergent adverse events
1
6 minute walk distance
1
six minute walk distance
1
adverse events
1
completion of 3 cycles
1
turnaround time for scan and marker data
1
forced vital capacity
1
forced expiratory volume in 1 second
1
fev1/fvc
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of Fisetin's 13 ongoing trials reports first?
"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women"; n 40; "Improved 6 minute walk"; 2027-11
NCT03675724
"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults"; n 40; "Decrease in blood inflammation markers"; 2027-11
NCT04476953
"COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation"; n 80; "Serious Adverse Events"; 2026-09
NCT04733534
"An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer"; n 110; "Change in walking speed"; 2027-12
NCT05593588
"Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency"; n 20; "Change in immunophenotyping of peripheral T lymphocytes"; 2026-12
NCT05595499
"Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors"; n 88; "Change in 6-minute walk distance (6MWD)"; 2028-08-14
7 further recorded trials
NCT06113016
"Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors"; n 164; "Change in 6 minute walk distance (6MWD)"; 2031-10-31
NCT06133634
"Fisetin to Improve Vascular Function in Older Adults"; n 70; "Change from baseline in endothelial function at 1 month"; 2027-03-31
NCT06399809
"Fisetin to Reduce Senescence and Mobility Impairment in PAD"; n 34; "Six-minute Walk Distance"; 2027-06
NCT06431932
"Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity"; n 60; "Population-based pharmacokinetic model for fisetin and metabolites"; 2028-12-31
NCT07025226
"Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease"; n 30; "Completion of 3 cycles"; 2027-09-01
NCT07195318
"Fisetin Supplementation for Healthy Aging"; n 120; "Soluble urokinase plasminogen activator receptor (suPAR)"; 2026-10-31
NCT07676435
"Ongoing Lung Decline With Age Intensified Response"; n 40; "Forced Vital Capacity (FVC)"; 2027-07-15
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which running trial of Fisetin could settle function?
NCT06399809 measures Six-minute Walk Distance, reading out 2027-06.
6 open trials; n 34; "Fisetin to Reduce Senescence and Mobility Impairment in PAD"
Show the evidence
Trial
NCT06399809
"Fisetin to Reduce Senescence and Mobility Impairment in PAD"; n 34; "Six-minute Walk Distance"; 2027-06
NCT03430037
"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women"; n 40; "Improved 6 minute walk"; 2027-11
NCT03675724
"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults"; n 40; "Decrease in blood inflammation markers"; 2027-11
NCT04733534
"An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer"; n 110; "Change in walking speed"; 2027-12
NCT05595499
"Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors"; n 88; "Change in 6-minute walk distance (6MWD)"; 2028-08-14
NCT06113016
"Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors"; n 164; "Change in 6 minute walk distance (6MWD)"; 2031-10-31
Q11
At the median, Fisetin's trials enrolled 40 people — anything larger?
Median enrolment
40
Largest enrolment
164
Registered trials counted
25
Q12
What is recorded about Fisetin and senolytic?
"Fisetin, a flavonoid from strawberries and apples, exerts senolytic activity by selectively eliminating senescent cells via PI3K/AKT and Bcl-2/Bcl-xL inhibition, with emerging clinical evidence." — where Fisetin and senolytic appear together. Europe PMC · pathway abstract search · 2026-09-01
"Fisetin, a flavonoid from strawberries and apples, exerts senolytic activity by selectively eliminating senescent cells via PI3K/AKT and Bcl-2/Bcl-xL inhibition, with emerging clinical evidence."
AMPKPMID 41515219
"Fisetin modulates several key signaling pathways, including NF-κB, Nrf2, AMPK, and SIRT1, leading to reduced inflammatory cytokine expression, enhanced antioxidant defenses, and improved lipid homeostasis."
sirtuinPMID 41515219
"Fisetin modulates several key signaling pathways, including NF-κB, Nrf2, AMPK, and SIRT1, leading to reduced inflammatory cytokine expression, enhanced antioxidant defenses, and improved lipid homeostasis."
senolyticPMID 41515219
"More importantly, fisetin is recognized as a potent senolytic agent, selectively activating pro-apoptotic pathways in senescent cells, which are known sources of inflammation and tissue damage."
mTORPMID 42193224
"RNA-sequencing revealed that AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR) signaling and mitophagy were involved in the protective effects of fisetin against ovarian aging."
AMPKPMID 42193224
"RNA-sequencing revealed that AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR) signaling and mitophagy were involved in the protective effects of fisetin against ovarian aging."
3 more recorded rows
mTORPMID 42193224
"Consistently, fisetin treatment promoted mitophagy, accompanied by AMPK/mTOR activation in ovarian tissues and GCs following D-gal exposure."
AMPKPMID 42193224
"Consistently, fisetin treatment promoted mitophagy, accompanied by AMPK/mTOR activation in ovarian tissues and GCs following D-gal exposure."
mTORPMID 42193224
"These findings indicate that fisetin prevents ovarian aging by suppressing follicular GC oxidative damage and ameliorating cell cycle arrest via activation of AMPK/mTOR-mediated mitophagy, thereby preserving female fertility."
autophagy
PMID 41475611
"Moreover, fisetin was found to enhance autophagy by inhibiting the PI3K/Akt/mTOR signaling pathway, subsequently reducing oxidative stress and pyroptosis, and ultimately improving ischemic flap survival."
PMID 41475611
"and Implications: Fisetin can improve the viability of ischemic flaps through the promotion of autophagy and reduction of pyroptosis, making it a potential candidate for clinical application."
sirtuinPMID 41881279
"The AI pipeline identified a computationally prioritized triad, fisetin, butein, and ursolic acid glucoside, whose predicted multi-target profile converges on AMPK-SIRT1 activation and ACC/FAS-mediated lipogenesis suppression."
autophagyPMID 42606694
"Overall, fisetin acts on multiple targets to protect neurons by reducing oxidative damage, supporting ion channel activity, and inducing the autophagy process."
senolyticPMID 42378907
"We critically evaluate the preclinical efficacy of senolytics (eg, dasatinib + quercetin, navitoclax, fisetin), and senomorphics (eg, rapamycin, metformin, melatonin, NLRP3 inhibitors) in preserving ovarian reserve, mitigating SASP-driven inflammation and fibrosis, and extending reproductive lifespan."
sirtuinPMID 37630770
"Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes."
recorded 2026-09-01 · last checked 2026-09-04
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