This page shows what was measured, who it was measured in, and what that does not settle.
What Minocycline does in the body
Infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility
From the FDA-approved label: The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. The tetracyclines, including minocycline, have a similar antimicrobial spectrum of activity against a wide range of gram-positive and gram-negative organisms. Cross-resistance of these organisms to tetracycline is common.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · 0020414E5U · read 2026-08-29
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 77 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer4 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Mood
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer2 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
pain intensity; time to pain resolution; pain threshold; pain tolerance
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
4 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
The primary outcome will be time to first blood stream infection defined by a positive blood culture from a sample that was clinically indicated and taken more than 48 hours after CVC insertion and up to 48 hours after CVC removal.
✗ The study did not show it
Who was studied
NCT01029717
How many people
1859
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
mRS score 0-1
✗ The study did not show it
Who was studied
NCT05836740
How many people
1724
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
The Absolute Change From Baseline in the Inflammatory Lesion Count at Week 12.
✗ The study did not show it
Who was studied
NCT03271021
How many people
1488
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Physical health-related quality of life (HRQoL)
✗ The study did not show it
Who was studied
NCT07280572
How many people
1250
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
The proportion of patients with favorable functional outcomes, defined as mRS 0-2 at 180 days.
✗ The study did not show it
Who was studied
NCT07305896
How many people
1248
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
What a body can do day to day
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
mRS score 0-3
✗ The study did not show it
Who was studied
NCT07338175
How many people
1192
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.3 registered measures of this kind. No reviewed result.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.10 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.4 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
clinical global impression scale
positive and negative syndrome scale total
montgomery asberg depression rating scale
symptom reduction
pain intensity
time to pain resolution
pain threshold
pain tolerance
hamilton depression scale scores
positive and negative syndrome scale
Measured
Things only a test, a scale or a device shows.
maximum observed plasma concentration
trough plasma concentration
time to reach maximum observed plasma concentration
inflammatory lesion counts at week 12
Meaningful
Things that change how a life goes, not only a number.
ischemic stroke
myocardial infarction
cardiovascular death
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (23)
long term efficacy
protocol compliance feasibility and adverse events
bioequivalence
combined auc for selected symptoms
positive symptoms
treatment effects on 5 selected symptoms
bcva
treatment response
depression symptoms
adverse events
modified rankin scale
clinical failures
adverse event
rapid visual information processing
pocket depth
elimination half life
transient ischemic attack
transition to psychotic disorder
experiencing treatment emergent adverse events
pod incidence
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Minocycline hydrochloride capsules, USP are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by rickettsiae. Respiratory tract infections caused by Mycoplasma pneumoniae. Lymphogranuloma venereum caused by Chlamydia trachomatis.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in pediatric patients below the age of 12 has not been established.”
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-30
On older people, the label states: “Clinical studies of Minocycline hydrochloride extended-release tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-30
On people who are pregnant, the label states: “Teratogenic Effects: Pregnancy category D [see Warnings and Precautions (5.1) ] Minocycline hydrochloride extended-release tablets should not be used during pregnancy.”
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-30
On people who are breastfeeding, the label states: “Tetracycline-class antibiotics are excreted in human milk.”
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S3.
No source is stored against this line.
What is in the pack
Sold as tablet, extended release, injectable, capsule, tablet, given by the oral, injection, topical route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Minocycline appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2172 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
drug intolerance — 322 reaction mentions
rheumatoid arthritis — 300 reaction mentions
arthralgia — 254 reaction mentions
drug hypersensitivity — 242 reaction mentions
pyrexia — 220 reaction mentions
non-hodgkin's lymphoma — 202 reaction mentions
joint swelling — 173 reaction mentions
polyarteritis nodosa — 158 reaction mentions
drug reaction with eosinophilia and systemic symptoms — 154 reaction mentions
skin hyperpigmentation — 147 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
155 products list this as an active ingredient in the United States drug directory. 155 of them contain it and nothing else.
FDA National Drug Code directory · 72162-1867 · read 2026-08-29
They are sold as aerosol, foam, capsule, injection, powder, tablet and tablet, extended release, taken intravenous, oral and topical.
FDA National Drug Code directory · 72162-1867 · read 2026-08-29
The regulator's established pharmacologic class for it is decreased prothrombin activity [pe], tetracycline-class drug [epc] and tetracyclines [cs].
FDA National Drug Code directory · 72162-1867 · read 2026-08-29
74 published labels name it as an active ingredient. 74 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-29
Minocycline Hydrochloride is oral at 3 DOSAGE FORMS & STRENGTHS 45 mg extended release tablets: grey coloured capsule shaped film coated tablets, debossed with “45”on one side, plain on other side. 55 mg extended release tablets:Pink coloured capsule shape…, recorded as fda label in effect 2026-05-04 in the United States.
US prescribing information · c11bfea8-6079-44ce-b8e1-20bfba631bec · read 2026-08-30
Recorded price in US: 0.17981–0.66549 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 29 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Minocycline studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Minocycline are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
How many documents were read
72 documents were read for this substance.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
0020414E5U
RxNorm concept
2375333
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Written into the record, not signed off.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
Suppression classes recorded: S3.
✓ Passed
Canonical metadata present
slug and display name present
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
41 approved applications cover products containing this substance. The earliest was NDA050315, approved 19710630 to TRIAX PHARMS.
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6 questions this page could not answer
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Recorded evidence blocks (11)
Q2
What did Minocycline's largest trial (1724 people) and its longest (21 years) measure?
1724 people in Minocycline's largest registered study, 21 years in its longest registered window, measuring mortality rate. ClinicalTrials.gov · 2026-09-01
75 phase2, 42 phase1, 41 phase4, 35 phase3, 25 na, 3 early phase1, 3 na or unstated; NCT03414502; 2029-03. Last human test completed 2026, NCT05902819.
Interpretation These counts include studies where Minocycline was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
75
phase1
42
phase4
41
phase3
35
na
25
early phase1
3
2 more recorded rows
na or unstated
3
Last recorded human testNCT05902819
2026-03-02
recorded 2026-09-01 · last checked 2026-09-04
Q3
From C. elegans to human: where has Minocycline shown lifespan?
292 mice; cohorts C2015; cohort rows are the workbook's own printed values; no median, percent change or survival statistic is derived from the per-animal data
Show the evidence
ITP cohortC2015
minocycline; 300; 6 months; f, m; ITP_C2015_Lifespan.xlsx
"Too much difficulty recruiting and retaining patients, PI decided to stop."; 28 of 196 registered studies
Show the evidence
Trial
NCT00240513
terminated; "Too much difficulty recruiting and retaining patients, PI decided to stop."
NCT00361257
terminated; "This study was terminated early due to futility."
NCT00378781
withdrawn; "Study withdrawn."
NCT00392223
terminated; "See Detailed Description"
NCT00401921
withdrawn; "PI moved to a new facility"
NCT00515255
terminated; "Recruitment Goal of 20 Not Met"
14 further recorded trials
NCT00836355
terminated; "Too few acute stroke patients available to meet enrollment requirements."
NCT00855062
terminated; "The Neurologic AIDS Research Consortium Data Safety and Monitoring Board committee recommended to terminate the study early due to futility on 11/6/2009."
NCT00930020
terminated; "interim analysis shows futility"
NCT01048983
withdrawn; "No accrual."
NCT01073813
terminated; "Lack of recruitment"
NCT01219673
terminated; "Low accrual."
NCT01349192
terminated; "Interim review showed a statistically significant treatment effect and the DMC recommended that the study be stopped with ongoing follow-up of enrolled subjects"
NCT01809340
terminated; "study team decision because of IP supply issue and necessary amendment to protocol"
NCT02055963
terminated; "Early termination due to the protocol lack of progress in improving accrual rate"
NCT02099240
terminated; "Not enough patient enrollment and lack of staffing"
NCT02113176
withdrawn; "Funding of minocycline"
NCT02178813
terminated; "Study stopped prematurely because of multiple logistic difficulties"
NCT02201563
terminated; "Very slow recruitment (only one patient was recruited)"
NCT02712775
withdrawn; "Study logistics"
recorded 2026-09-01 · last checked 2026-09-04
Q6
Mouse studies of Minocycline used 300 ppm — over how long?
studies of Minocycline used the recorded amount. clinicaltrials.gov+jax-mpd-itp · 2026-09-04
18 recorded entries; mouse, human; capsule; also "300 ppm", "Minocycline 100mg/Placebo 0mg", "Minocycline 100mg Tablets"
Show the evidence
mouseminocycline C2015
300 ppm
human
NCT00401921
Minocycline 100mg/Placebo 0mg
NCT00776542
Minocycline 100mg Tablets
NCT01647282
locally-applied minocycline HCl (1 mg)
NCT01647282
Arestin (minocycline microspheres) 1 mg
NCT01755611
Minocycline 100mg
NCT03106740
Minocycline Hydrochloride 100mg Capsule
11 more recorded rows
humanNCT04020588
Minocycline 100 mg
humanNCT04202263
Minocycline 0%
humanNCT04940767
Amzeeq 4% Topical Foam
humanNCT05014906
Minocycline 45 MG
humanNCT06027151
1ml of 2% minocycline gel
humanNCT06027151
1ml of combination of 1% metronidazole gel and 2% minocycline
humanNCT06537921
Minocycline 200mg
humanNCT07526987
capsule; Minocycline Hydrochloride Capsule (50 mg per capsule)
humanNCT07526987
capsule; Placebo of Minocycline Hydrochloride Capsule (50 mg per capsule, containing 0 mg of minocycline)
humanNCT07750938
Minocycline 100 mg (10-Day Regimen)
humanNCT07750938
Minocycline 100 mg (14-Day Regimen)
recorded 2026-09-04 · last checked 2026-09-04
Q7
Which of adverse event, adverse events and bcva did Minocycline's trials measure?
combined auc for selected symptoms, clinical global impression scale, positive symptoms, treatment effects on 5 selected symptoms, bcva and positive and negative syndrome scale total follow.
Show the evidence
long term efficacy
1
protocol compliance feasibility and adverse events
1
bioequivalence
1
combined auc for selected symptoms
1
clinical global impression scale
1
positive symptoms
1
14 more recorded rows
treatment effects on 5 selected symptoms
1
bcva
1
positive and negative syndrome scale total
1
treatment response
1
depression symptoms
1
adverse events
1
montgomery asberg depression rating scale
1
symptom reduction
1
modified rankin scale
1
pain intensity
1
time to pain resolution
1
clinical failures
1
adverse event
1
rapid visual information processing
1
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which of Minocycline's 20 ongoing trials reports first?
Post-op Atrial Fibrillation; Efficacy of Disease-modifying Antirheumatic Drugs Therapy for Rheumatoid Arthritis; latest 2032-01
Show the evidence
Trial
NCT01422148
"Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery"; n 60; "Post-op Atrial Fibrillation"; 2028-01-24
NCT03414502
"Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response"; n 400; "Efficacy of Disease-modifying Antirheumatic Drugs Therapy for Rheumatoid Arthritis"; 2029-03
NCT05474729
"Minocycline for Chronic Autoimmune Uveitis"; n 10; "Change of macular sensitivity"; 2026-12-31
NCT05512910
"Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)"; n 90; "The expanded NIH Stroke Scale (e-NIHSS) at 5-7 days or at discharge"; 2025-06-04
NCT05605366
"Minocycline In Neurocognitive Outcomes - Sickle Cell Disease"; n 30; "Safety and tolerability of prolonged minocycline exposure in adult patients with SCD"; 2028-06-15
NCT05826912
"Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury"; n 672; "Change in Glasgow Outcome Scale-Extended (GOSE 2-Way)"; 2029-08-31
14 further recorded trials
NCT06120140
"Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib"; n 305; "Number of Participants With Grade Greater Than or Equal to (>=) 2 Dermatologic Adverse Events of Interest (DAEIs) Within 12 Weeks After Initiation of Anticancer Treatment"; 2030-06-30
NCT06246396
"Antihypertensive Mechanisms of Minocycline in Resistant Hypertension"; n 120; "24-h systolic blood pressure"; 2028-07
NCT06523764
"Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment"; n 208; "Helicobacter pylori eradication rate"; 2025-10-01
NCT06537921
"Comorbid Obesity and Depression With an Anti-inflammatory Medication"; n 35; "Enrolment rate"; 2027-09-01
NCT06699966
"Stony Brook Medicine Anti-Inflammatory Trial"; n 42; "Change from Baseline Hamilton Depression Rating Scale (HAM-D 24) Score at 8 Weeks"; 2032-01
NCT07068607
"Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial"; n 400; "Helicobacter pylori eradication"; 2025-11-01
NCT07082855
"A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa"; n 126; "The change of ERG"; 2028-06-30
NCT07237048
"Minocycline in Stroke Study at Maimonides"; n 1164; "Change in National Institutes of Health Stroke Scale (NIHSS) Score at Day 7 post stroke"; 2028-12
NCT07305896
"Efficacy and Safety of Minocycline in the Treatment of Intracerebral Hemorrhage"; n 1248; "The proportion of patients with favorable functional outcomes, defined as mRS 0-2 at 180 days."; 2028-12-31
NCT07338175
"Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage"; n 1192; "mRS score 0-3"; 2028-12
NCT07526987
"Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis"; n 934; "Excellent functional outcome (mRS of 0-1)"; 2028-12-31
NCT07594301
"Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)"; n 234; "Functional independence"; 2028-12
NCT07594314
"Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)"; n 860; "Excellent outcome"; 2028-12
NCT07750938
"Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression"; n 316; "H. pylori Eradication Rate"; 2028-08-10
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 55 trials of Minocycline posted no result?
Posted no result
55 of 55 completed trials
Registrations
NCT00776542, NCT00777413, NCT00029874, NCT00063193, NCT00579644 and NCT00047723, and 49 more
Completion dates
oldest 2003-01; newest 2024-08-15
Show the evidence
Trial
NCT00776542
2003-01
NCT00777413
2003-01
NCT00029874
2003-08
NCT00063193
2005-07
NCT00579644
2006-05-31
NCT00047723
2007-01
14 further recorded trials
NCT00733057
2007-03
NCT00355576
2007-05
NCT00630942
2007-05
NCT00456677
2007-10-01
NCT00916461
2008-03
NCT00243893
2008-10
NCT02312297
2008-12
NCT02312609
2008-12
NCT00536042
2009-06
NCT01049438
2009-09
NCT01064752
2009-10
NCT00559494
2010-08
NCT01755611
2011-06-25
NCT05014906
2011-09
Q10
At the median, Minocycline's trials enrolled 47 people — anything larger?
Median enrolment
47
Largest enrolment
1724
Registered trials counted
194
Q11
What do 2172 spontaneous reports say about Minocycline — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Minocycline appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2172 reaction mentions were counted: drug intolerance 322; rheumatoid arthritis 300; arthralgia 254; drug hypersensitivity 242. open-targets-adr · CHEMBL1200881 · 2026-06-24
Show the evidence
drug intolerance
322
rheumatoid arthritis
300
arthralgia
254
drug hypersensitivity
242
pyrexia
220
non-hodgkin's lymphoma
202
4 more recorded rows
joint swelling
173
polyarteritis nodosa
158
drug reaction with eosinophilia and systemic symptoms
154
skin hyperpigmentation
147
recorded 2026-06-24 · last checked 2026-09-04
Q12
What is recorded about Minocycline and AMPK?
"To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor)." — where Minocycline and AMPK appear together. Europe PMC · pathway abstract search · 2026-02-14
"To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor)."
sirtuinPMID 41698615
"To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor)."
IGF-1PMID 37524449
"Furthermore, the PI3K/AKT pathway inhibitor LY294002, and activator IGF-1 were used to confirm the mechanism of minocycline."
autophagyPMID 37524449
"In addition, minocycline treatment upregulated autophagy response in damaged spinal cord through increasing LC3B, Beclin-1 and decreasing P62."
mTORPMID 37524449
"Minocycline could improve neuropathic pain induced by SCI through activating autophagy and inhibiting PI3K/AKT/mTOR pathway."
autophagyPMID 37524449
"Minocycline could improve neuropathic pain induced by SCI through activating autophagy and inhibiting PI3K/AKT/mTOR pathway."
NAD+
"Minocycline may extend lifespan by caloric restriction, preventing declines in NAD<sup>+</sup>, modulating of the gut environment and decreasing inflammageing.</p>"
"These results suggest that minocycline may inhibit NAD⁺ consumers more effectively than existing inhibitors, potentially preserving NAD⁺ levels and mitigating the ageing process."
autophagyPMID 33950542
"By administration autophagy inhibitor 3-Methyladenine, PDGFRβ inhibitor imatinib, p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 hydrochloride and minocycline hydrochloride, western blot, immunofluorescence, and transmission electron microscopy techniques were used to elucidate the roles of PDGFRβ, autophagy, and related signaling pathways in morphine tolerance."
sirtuin
PMID 33021962
"We also used minocycline, a well-known inhibitor of microglial activation, to study the mechanism of SIRT1 signaling."
PMID 33021962
"Our findings demonstrated that SIRT1 participates in the maintenance of microglial polarization homeostasis and that minocycline exerts regulatory effects on SIRT1 activation."
mTOR
PMID 32766308
"Minocycline, which induces autophagy by inhibiting mTOR, suppresses cytokine production and cell proliferation and protects THP-1 cells from LPS toxicity."
PMID 32766308
"In addition, rapamycin, the mTOR inhibitor, has cooperative effect with minocycline on suppression of TNF-<i>α</i> release and induction of autophagy by repressing mTOR."
IGF-1
"Finally, we use STAT1 inhibitor or minocycline to evaluated the role of STAT1 in mediating the microglial priming and effects of primed microglia in IFN-γ-induced social dysfunction. <bold>Results: </bold>We demonstrated that 500 ng of IFN-γ injection results in significant decrease in social index and social novelty recognition index, and induces microglial priming in hippocampus, characterized…"
AMPKPMID 30198433
"Minocycline effectively inhibits oxidative stress via modulating antioxidative enzymes and activating the LKB1/AMPK signaling pathway in the process of acute cerebral infarct."
recorded 2026-02-14 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · NIA ITP via the JAX Mouse Phenome Database · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.