CoQ10 / Ubiquinol
Evidence: ★★★☆☆ · Status: OTC Supplement
In plain English
A spark plug inside your cellular engines. Statin drugs quietly drain it, causing muscle aches — replacing it fixes that. Most valuable for statin users and heart failure.
How it works
Electron carrier in mitochondrial Complex I→III of the electron transport chain and a lipid-phase antioxidant. Statins block the mevalonate pathway that makes both cholesterol and CoQ10, causing depletion and muscle pain.
Molecular target & official sources
COQ2 (NCBI Gene) · Ubiquinol (PubChem CID 5283546)
Protocol
100–300 mg with fat; ubiquinol if 40+ or on statins.
Bottom line
Effectively mandatory alongside statins.
Helps with: Build Muscle & Strength · Endurance · Live Longer · Cardiovascular
Stacks with
Take with a fatty meal (fat-soluble); statin users benefit most, since statins deplete CoQ10.
Shares a pathway — often paired with: Metformin, Statins (Atorvastatin/Rosuvastatin), Magnesium, Iron.
Availability & where to buy
Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving. ~S$25–50/month; ubiquinol absorbs better than plain ubiquinone, especially over 40.
How it works: the Mitochondria pathway →
Used in these protocols
Common questions
Does CoQ10 / Ubiquinol actually work?
Human-evidence rating: 3 of 5. Effectively mandatory alongside statins.
How do you take CoQ10 / Ubiquinol?
100–300 mg with fat; ubiquinol if 40+ or on statins.
Is CoQ10 / Ubiquinol legal or approved?
Regulatory status: OTC Supplement.