Yohimbine

Evidence: ★★★☆☆ · Status: OTC Supplement, Prescription

💡 Did you know? Yohimbine only releases stubborn fat when you're fasted — even a little insulin from food switches its fat-burning effect off.

In plain English

Some fat areas have "do not burn" locks. Yohimbine picks those locks — best on an empty stomach before cardio. Can spike anxiety and heart rate.

How it works

Alpha-2 adrenergic (ADRA2A) antagonist. Alpha-2 receptors normally block fat release in "stubborn" areas (lower body); blocking them plus boosting norepinephrine unlocks lipolysis there — most effective fasted.

Molecular target & official sources

ADRA2A alpha-2A adrenergic receptor (NCBI Gene) · Yohimbine (PubChem CID 8969)

Protocol

0.2 mg/kg fasted, pre-cardio.

Watch out

Anxiety, palpitations, BP; avoid with caffeine sensitivity or hypertension.

Bottom line

Small, real effect on stubborn fat when already lean and fasted.

Helps with: Lose Fat · Cardiovascular · Stress & Anxiety

Stacks with

Shares a pathway — often paired with: Caffeine, Semaglutide (Ozempic / Wegovy / Rybelsus), Tirzepatide (Mounjaro / Zepbound), Modafinil / Armodafinil.

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

How it works: the GPCR → cAMP pathway →

Used in these protocols

Common questions

Does Yohimbine actually work?

Human-evidence rating: 3 of 5. Small, real effect on stubborn fat when already lean and fasted.

How do you take Yohimbine?

0.2 mg/kg fasted, pre-cardio.

What are the risks or side effects of Yohimbine?

Anxiety, palpitations, BP; avoid with caffeine sensitivity or hypertension.

Is Yohimbine legal or approved?

Regulatory status: OTC Supplement, Prescription.