TB-500 (Thymosin Beta-4 fragment)
Evidence: ★★☆☆☆ · Status: Not Approved
In plain English
Helps repair cells physically crawl to the site of damage and calms inflammation — a more "whole-body" healer than BPC-157's local action. Usually stacked with BPC-157. Human data is anecdotal.
How it works
Fragment of thymosin β4 (TMSB4X); regulates actin polymerisation to enable cell migration to wounds, promotes angiogenesis, and reduces inflammation. Studied in cardiac and corneal repair models.
Molecular target & official sources
TMSB4X thymosin beta 4 (NCBI Gene) · TB-500 (PubChem)
Bottom line
Plausible from animal work; no human trials. Commonly paired with BPC-157.
Helps with: Recover Faster · Stress & Anxiety
Stacks with
Shares a pathway — often paired with: Omega-3 (EPA/DHA), Statins (Atorvastatin/Rosuvastatin), SGLT2 Inhibitors (Empagliflozin / Canagliflozin), Saffron (Crocus sativus).
Availability & where to buy
Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.
How it works: the NF-κB / Inflammation pathway →
Used in these protocols
Common questions
Does TB-500 (Thymosin Beta-4 fragment) actually work?
Human-evidence rating: 2 of 5. Plausible from animal work; no human trials. Commonly paired with BPC-157.
Is TB-500 (Thymosin Beta-4 fragment) legal or approved?
Regulatory status: Not Approved.