🧬 RNAwiki

NF-κB / Inflammation

💡 Did you know? Ginger and turmeric aren't roots — they're underground stems (rhizomes) — and both calm inflammation through the same master switch, NF-κB.

In one line: Your body's master inflammation switch. A little is healing; stuck-on is corrosive.

Picture this: NF-κB is a master switch that turns on inflammation genes. When you're injured or infected, flipping it on is exactly right — it summons healing and defence. But if it stays switched on quietly for years ("inflammaging"), it drives joint pain, poor recovery, and most age-related disease.

Step by step:

  1. A trigger — injury, infection, or chronic stress — activates NF-κB.
  2. NF-κB moves into the cell's control room and switches on inflammation genes.
  3. The cell releases inflammatory messengers that cause swelling, pain, and immune activity.
  4. Normally this resolves; when it doesn't, low-grade inflammation smoulders for years.

Why it matters for you: Most "anti-inflammatory" supplements work by quieting this switch. Omega-3, curcumin, and boswellia genuinely lower it — helping recovery, joints, and long-term health.

Turn it down: omega-3, curcumin (the absorbable forms), boswellia, sulforaphane, good sleep. Don't be fooled: blocking all inflammation right after training can slightly blunt the adaptation you're training for — time heavy anti-inflammatories away from the workout you want to grow from.