MOTS-c

Evidence: ★★☆☆☆ · Status: Not Approved

💡 Did you know? MOTS-c is a rare hormone coded not by your main DNA but by your mitochondria — your cells' power plants send out their own signals.

In plain English

A tiny signal your mitochondria themselves release to say "burn fuel efficiently, adapt like you exercised." It drops with age; supplementing it improved metabolism in animals.

How it works

Mitochondrial-derived peptide (encoded in mtDNA 12S rRNA) that activates AMPK, improves insulin sensitivity and metabolic flexibility, and acts as an exercise mimetic; declines with age.

Molecular target & official sources

PRKAA1 AMPK (NCBI Gene) · MOTS-c review (PMC)

Bottom line

Exciting mitochondrial-aging biology; human data pending.

Helps with: Live Longer

Stacks with

Shares a pathway — often paired with: Metformin, Statins (Atorvastatin/Rosuvastatin), Magnesium, Berberine.

Availability & where to buy

Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.

How it works: the AMPK pathway →

Common questions

Does MOTS-c actually work?

Human-evidence rating: 2 of 5. Exciting mitochondrial-aging biology; human data pending.

Is MOTS-c legal or approved?

Regulatory status: Not Approved.