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MK-677 (Ibutamoren)

Evidence: ★★★☆☆ · Status: Not Approved

💡 Did you know? MK-677 fakes the hunger hormone ghrelin, which is why it raises growth hormone — and appetite — without an injection.

In plain English

A pill (not an injection) that keeps growth hormone elevated via the ghrelin switch — famous for deep sleep and appetite, plus fuller muscles. Downsides are water retention and higher blood sugar.

How it works

Orally-active non-peptide GHSR agonist; sustained GH/IGF-1 elevation and marked slow-wave-sleep enhancement (GH pulses in deep sleep). Reversed nitrogen wasting in trials.

Molecular target & official sources

GHSR (NCBI Gene) · Ibutamoren (PubChem CID 636866)

Protocol

10–25 mg at night.

Watch out

Raised fasting glucose, water retention, joint aches; not for diabetics or active cancer.

Bottom line

The most practical GH-optimiser without a needle.

Helps with: Build Muscle & Strength · Lose Fat · Recover Faster · Sleep Better · Hormones & Testosterone

Stacks with

Shares a pathway — often paired with: EPO (Erythropoietin), Tesamorelin (Egrifta), Human Growth Hormone (Somatropin), Insulin (anabolic misuse).

Availability & where to buy

Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.

How it works: the PI3K/Akt growth factor pathway →

Compare MK-677 (Ibutamoren)

Common questions

Does MK-677 (Ibutamoren) actually work?

Human-evidence rating: 3 of 5. The most practical GH-optimiser without a needle.

How do you take MK-677 (Ibutamoren)?

10–25 mg at night.

What are the risks or side effects of MK-677 (Ibutamoren)?

Raised fasting glucose, water retention, joint aches; not for diabetics or active cancer.

Is MK-677 (Ibutamoren) legal or approved?

Regulatory status: Not Approved.