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Low-Dose Lithium

Evidence: ★★☆☆☆ · Status: OTC Supplement, Prescription

💡 Did you know? Regions with more natural lithium in their tap water tend to have lower suicide rates — a clue behind interest in tiny 'microdose' lithium.

In plain English

At tiny doses (far below psychiatric levels), the mineral lithium may protect the aging brain — populations drinking more of it naturally live a bit longer. Very preliminary.

How it works

Inhibits GSK-3β and induces autophagy/neuroprotection; regions with higher trace lithium in water show lower all-cause and suicide mortality.

Molecular target & official sources

GSK3B (NCBI Gene) · Lithium (PubChem CID 3028194)

Protocol

Lithium orotate 1–5 mg elemental (microdose).

Bottom line

Intriguing neuroprotective microdose signal; not established.

Helps with: Live Longer

Stacks with

Shares a pathway — often paired with: Rapamycin (Sirolimus), SGLT2 Inhibitors (Empagliflozin / Canagliflozin), Fisetin, Quercetin + Dasatinib (D+Q).

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

How it works: the Senescence / Autophagy pathway →

Common questions

Does Low-Dose Lithium actually work?

Human-evidence rating: 2 of 5. Intriguing neuroprotective microdose signal; not established.

How do you take Low-Dose Lithium?

Lithium orotate 1–5 mg elemental (microdose).

Is Low-Dose Lithium legal or approved?

Regulatory status: OTC Supplement, Prescription.