Fisetin

Evidence: ★★★☆☆ · Status: OTC Supplement

💡 Did you know? Fisetin, a compound found in strawberries, can clear 'zombie' senescent cells in animal studies — an entire anti-ageing strategy hiding in a fruit.

In plain English

As you age, damaged cells refuse to die and instead sit around leaking inflammation ("zombie cells"). Fisetin selectively kills them. Taken as a monthly 2-day pulse, not daily.

How it works

Flavonoid senolytic — selectively kills senescent "zombie" cells by inhibiting their survival (SCAP) pathways (BCL-2 / PI3K-AKT anti-apoptotic network). Reduced senescent burden and extended median lifespan in aged mice (Mayo Clinic).

Molecular target & official sources

BCL2L1 anti-apoptotic (NCBI Gene) · Fisetin (PubChem CID 5281614)

Protocol

500–1,000 mg/day, 2 consecutive days monthly, with fat.

Bottom line

Most credible dietary senolytic; low risk, human trials ongoing.

Helps with: Recover Faster · Live Longer

Stacks with

Shares a pathway — often paired with: Omega-3 (EPA/DHA), Rapamycin (Sirolimus), EPO (Erythropoietin), Statins (Atorvastatin/Rosuvastatin).

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the PI3K/Akt growth factor pathway →

Used in these protocols

Longevity / Healthspan

Common questions

Does Fisetin actually work?

Human-evidence rating: 3 of 5. Most credible dietary senolytic; low risk, human trials ongoing.

How do you take Fisetin?

500–1,000 mg/day, 2 consecutive days monthly, with fat.

Is Fisetin legal or approved?

Regulatory status: OTC Supplement.