Citrus Bergamot

Evidence: ★★★☆☆ · Status: OTC Supplement

💡 Did you know? Bergamot — the citrus that gives Earl Grey tea its scent — has polyphenols shown to lower LDL cholesterol.

In plain English

A citrus extract that gently lowers cholesterol through the same enzyme statins target — a natural option for mild dyslipidemia.

How it works

Polyphenols inhibit HMG-CoA reductase (statin-like) and activate AMPK, lowering LDL and triglycerides and raising HDL.

Molecular target & official sources

HMGCR HMG-CoA reductase (NCBI Gene) · Examine: bergamot

Protocol

500–1,000 mg/day.

Bottom line

Reasonable natural lipid support.

Helps with: Cardiovascular

Stacks with

Shares a pathway — often paired with: Metformin, Berberine, Alpha-Lipoic Acid (ALA), MOTS-c.

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the AMPK pathway →

Used in these protocols

High Cholesterol / Lipids

Common questions

Does Citrus Bergamot actually work?

Human-evidence rating: 3 of 5. Reasonable natural lipid support.

How do you take Citrus Bergamot?

500–1,000 mg/day.

Is Citrus Bergamot legal or approved?

Regulatory status: OTC Supplement.