HMGCR
HMGCR HMG-CoA reductase — the molecular target that 2 compounds in the wiki act on.
In one line: The enzyme your liver uses to make cholesterol — and the one statins block.
HMGCR is the key enzyme in the assembly line your liver uses to manufacture cholesterol. Statins — the most prescribed heart drugs in the world — work by jamming this enzyme. With less cholesterol being made internally, your liver pulls more of it out of your bloodstream, lowering the "bad" LDL that clogs arteries.
This is one of the best-evidenced interventions in all of medicine for preventing heart attacks. Red yeast rice contains a natural version of a statin that works the same way.
One side note worth knowing: the same assembly line also makes CoQ10, a molecule your muscles' energy factories need. Statins lower it too, which is why some people on statins get muscle aches — and why CoQ10 is often taken alongside.