Anastrozole / Exemestane (Aromatase Inhibitors) vs Melanotan II
Both are used for sexual health. Here's how they compare on human evidence, mechanism, safety and availability — in plain English.
| Anastrozole / Exemestane (Aromatase Inhibitors) | Melanotan II | |
|---|---|---|
| Human evidence | ★★★★☆ | ★★☆☆☆ |
| Legal status | Prescription, Off-Label | Not Approved |
| How it works | Inhibit aromatase (CYP19A1), the enzyme converting testosterone to estradiol. Anastrozole is reversible; exemestane is a suicide (irreversible) inhibitor. | Non-selective melanocortin agonist (MC1R tanning + MC4R libido/appetite); darkens skin and raises libido. |
| In plain English | High testosterone partly converts to estrogen, which can cause bloating and gyno. These drugs block that conversion. Easy to overdo — crashing estrogen wrecks mood, joints, and libido. | Tans skin and boosts libido by hitting melanocortin receptors — but it also darkens moles and its long-term safety (including melanoma concern) is unknown. |
| Bottom line | Use only if estradiol is genuinely high; low estrogen is as bad as high. | Effective tanning/libido effect, real unresolved safety questions. |
| Availability | Prescription only | Not widely approved |
Which is better for sexual health?
Anastrozole / Exemestane (Aromatase Inhibitors) has the stronger human-evidence rating (★★★★☆ vs ★★☆☆☆), but the right choice still depends on your goal, tolerance and budget.
Full breakdowns: Anastrozole / Exemestane (Aromatase Inhibitors) · Melanotan II.
Common questions
Is Anastrozole / Exemestane (Aromatase Inhibitors) or Melanotan II better for sexual health?
Anastrozole / Exemestane (Aromatase Inhibitors) has the stronger human-evidence rating (★★★★☆ vs ★★☆☆☆), but the right choice still depends on your goal, tolerance and budget.
What's the difference between Anastrozole / Exemestane (Aromatase Inhibitors) and Melanotan II?
Anastrozole / Exemestane (Aromatase Inhibitors): Use only if estradiol is genuinely high; low estrogen is as bad as high. — Melanotan II: Effective tanning/libido effect, real unresolved safety questions.