Anastrozole / Exemestane (Aromatase Inhibitors)

Evidence: ★★★★☆ · Status: Prescription, Off-Label

In plain English

High testosterone partly converts to estrogen, which can cause bloating and gyno. These drugs block that conversion. Easy to overdo — crashing estrogen wrecks mood, joints, and libido.

How it works

Inhibit aromatase (CYP19A1), the enzyme converting testosterone to estradiol. Anastrozole is reversible; exemestane is a suicide (irreversible) inhibitor.

Molecular target & official sources

CYP19A1 aromatase (NCBI Gene) · Anastrozole (PubChem CID 2187)

Bottom line

Use only if estradiol is genuinely high; low estrogen is as bad as high.

Helps with: Joint Health · Hormones & Testosterone · Stress & Anxiety · Sexual Health

Stacks with

Shares a pathway — often paired with: Omega-3 (EPA/DHA), Vitamin D3 (+ K2), Testosterone (TRT), Finasteride / Dutasteride.

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

How it works: the Nuclear receptors pathway →

Compare Anastrozole / Exemestane (Aromatase Inhibitors)

• Anastrozole / Exemestane (Aromatase Inhibitors) vs Omega-3 (EPA/DHA)
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Collagen Peptides (+ Vitamin C)
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Glucosamine + Chondroitin
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Vitamin C (Ascorbate)
• Anastrozole / Exemestane (Aromatase Inhibitors) vs SAM-e (S-Adenosylmethionine)
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Boron
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Glycine
• Anastrozole / Exemestane (Aromatase Inhibitors) vs Testosterone (TRT)