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Resveratrol / Pterostilbene

Evidence: ★★☆☆☆ · Status: OTC Supplement

💡 Did you know? The famous 'red wine' longevity molecule, resveratrol, is real — but you'd need to drink hundreds of glasses a day to match a study dose.

In plain English

The "red wine molecule" and its more absorbable cousin flip on the same longevity genes (sirtuins) that fasting does. Human results have been underwhelming for resveratrol (poor absorption); pterostilbene absorbs much better.

How it works

Polyphenol SIRT1 activators (sirtuin pathway, overlaps caloric-restriction signalling). Pterostilbene is the dimethylated form — far better bioavailability and half-life.

Molecular target & official sources

SIRT1 (NCBI Gene) · Resveratrol (PubChem CID 445154)

Protocol

Pterostilbene 100–250 mg; often paired with NMN/NR.

Bottom line

Weak human evidence; pterostilbene the better-absorbed choice.

Helps with: Live Longer

Stacks with

Shares a pathway — often paired with: NMN / NR (NAD⁺ precursors), Niacin / NADH (Vitamin B3).

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the NAD⁺ / Sirtuins pathway →

Used in these protocols

Longevity / Healthspan

Common questions

Does Resveratrol / Pterostilbene actually work?

Human-evidence rating: 2 of 5. Weak human evidence; pterostilbene the better-absorbed choice.

How do you take Resveratrol / Pterostilbene?

Pterostilbene 100–250 mg; often paired with NMN/NR.

Is Resveratrol / Pterostilbene legal or approved?

Regulatory status: OTC Supplement.