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Niacin / NADH (Vitamin B3)

Evidence: ★★★☆☆ · Status: OTC Supplement

💡 Did you know? A niacin (B3) deficiency causes pellagra — the 'four Ds': dermatitis, diarrhoea, dementia, and death. A little in your food quietly prevents it.

In plain English

The cheapest way to raise NAD⁺ (your cellular energy coenzyme) — though it causes a hot "flush." NMN/NR are the flush-free modern versions.

How it works

Direct NAD⁺ precursor (salvage pathway); high-dose niacin also raises HDL and lowers Lp(a) via hepatic effects.

Molecular target & official sources

NAMPT (NCBI Gene) · Niacin (PubChem CID 938)

Bottom line

Cheap NAD⁺ route; flushing limits it.

Stacks with

Shares a pathway — often paired with: NMN / NR (NAD⁺ precursors), Resveratrol / Pterostilbene.

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the NAD⁺ / Sirtuins pathway →

Common questions

Does Niacin / NADH (Vitamin B3) actually work?

Human-evidence rating: 3 of 5. Cheap NAD⁺ route; flushing limits it.

Is Niacin / NADH (Vitamin B3) legal or approved?

Regulatory status: OTC Supplement.