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Psilocybin / Microdosing

Evidence: ★★★☆☆ · Status: Prescription, Controlled

💡 Did you know? In depression trials, a single guided psilocybin session can shift mood for weeks — acting on the same serotonin receptor (5-HT2A) as classic psychedelics.

In plain English

Full-dose (with therapy) shows real, lasting antidepressant effects via a burst of brain plasticity. Sub-perceptual "microdosing" is mostly placebo in controlled trials.

How it works

5-HT2A serotonin receptor (HTR2A) agonist driving neuroplasticity (BDNF, dendritic growth); breakthrough-therapy status for depression. Microdosing evidence is far weaker than full-dose therapy.

Molecular target & official sources

HTR2A 5-HT2A receptor (NCBI Gene) · Psilocybin (PubChem CID 10624)

Bottom line

Macro-dose therapy is the real signal; microdosing hype outruns data.

Helps with: Stress & Anxiety

Stacks with

Shares a pathway — often paired with: Caffeine, Modafinil / Armodafinil, Amphetamine (Adderall) / Lisdexamfetamine (Vyvanse), Methylphenidate (Ritalin).

Availability & where to buy

Controlled substance. A controlled substance in most countries — illegal to buy, sell or possess without authorisation (in Singapore: HSA / CNB). Education only.

How it works: the Monoamines pathway →

Common questions

Does Psilocybin / Microdosing actually work?

Human-evidence rating: 3 of 5. Macro-dose therapy is the real signal; microdosing hype outruns data.

Is Psilocybin / Microdosing legal or approved?

Regulatory status: Prescription, Controlled.