IGF-1 LR3

Evidence: ★★☆☆☆ · Status: Not Approved

In plain English

The growth factor GH actually works through, injected directly. Potent muscle-growth signal — but IGF-1 also feeds tumours and drops blood sugar dangerously.

How it works

Long-acting insulin-like growth factor-1 analog binding IGF1R, driving hyperplasia (new muscle cells) and protein synthesis; LR3 modification evades IGF-binding proteins for extended action.

Molecular target & official sources

IGF1R IGF-1 receptor (NCBI Gene) · IGF-1 (PubChem)

Watch out

Hypoglycemia, cancer-growth concern, organ growth.

Bottom line

High potency, high risk, no human safety data for this use.

Helps with: Build Muscle & Strength · Hormones & Testosterone

Stacks with

Shares a pathway — often paired with: EPO (Erythropoietin), Tesamorelin (Egrifta), Human Growth Hormone (Somatropin), Insulin (anabolic misuse).

Availability & where to buy

Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.

How it works: the PI3K/Akt growth factor pathway →