Hexarelin / GHRP-2 / GHRP-6

Evidence: ★★☆☆☆ · Status: Not Approved

In plain English

First-generation ghrelin peptides — powerful GH release but with side baggage (hunger, stress hormones) that ipamorelin was designed to fix.

How it works

Older GHSR agonists; strong GH release but also raise cortisol/prolactin (GHRP-2) and hunger (GHRP-6); hexarelin is most potent but desensitises fastest.

Molecular target & official sources

GHSR (NCBI Gene) · GHRP-6 (PubChem CID 9938226)

Bottom line

Largely replaced by ipamorelin.

Helps with: Build Muscle & Strength · Hormones & Testosterone · Stress & Anxiety

Stacks with

Shares a pathway — often paired with: Magnesium, Phentermine / Qsymia (phentermine-topiramate), Ashwagandha (Withania somnifera), Vitamin C (Ascorbate).

Availability & where to buy

Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.

How it works: the HPA axis pathway →