GlyNAC (Glycine + NAC)
Evidence: ★★★☆☆ · Status: OTC Supplement
In plain English
Older bodies run low on glutathione (the main antioxidant). Giving both building blocks restocks it, and small human trials showed improvements across many aging measures at once.
How it works
Supplies both substrates for glutathione synthesis, restoring the depleted master antioxidant in aging; improved mitochondrial function, insulin sensitivity, and multiple aging hallmarks in Baylor human trials.
Molecular target & official sources
GCLC (NCBI Gene) · Glutathione (PubChem CID 124886)
Protocol
Glycine ~100 mg/kg + NAC ~100 mg/kg daily (trial doses; high).
Bottom line
Among the better human-trial-supported longevity stacks.
Helps with: Live Longer
The human evidence
Small trials from Baylor (Kumar/Sekhar) show that combining glycine and NAC restores glutathione and improves mitochondrial function, strength and several aging markers in older adults better than either alone. Early but mechanistically coherent.
Stacks with
It is the stack — glycine + NAC. Glycine also aids sleep on its own.
Shares a pathway — often paired with: Metformin, Statins (Atorvastatin/Rosuvastatin), Magnesium, Iron.
Availability & where to buy
Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving. Cheap — buy plain glycine and NAC separately for a fraction of branded "GlyNAC" products.
How it works: the Mitochondria pathway →
Used in these protocols
Common questions
Does GlyNAC (Glycine + NAC) actually work?
Human-evidence rating: 3 of 5. Among the better human-trial-supported longevity stacks.
How do you take GlyNAC (Glycine + NAC)?
Glycine ~100 mg/kg + NAC ~100 mg/kg daily (trial doses; high).
Is GlyNAC (Glycine + NAC) legal or approved?
Regulatory status: OTC Supplement.