DSIP (Delta Sleep-Inducing Peptide, Emideltide)
Evidence: ★★☆☆☆ · Status: Not Approved
In plain English
A natural "go into deep sleep" signal peptide, also studied for stress and pain. Under the July 2026 FDA compounding review.
How it works
Endogenous nonapeptide modulating delta-wave (deep) sleep, the HPA axis, and stress resilience; exact receptor unresolved.
Molecular target & official sources
DSIP (PubChem CID 68816) · Frontiers review
Bottom line
Intriguing sleep/stress peptide; limited modern data.
Helps with: Recover Faster · Sleep Better · Stress & Anxiety
Stacks with
Shares a pathway — often paired with: Magnesium, Phentermine / Qsymia (phentermine-topiramate), Ashwagandha (Withania somnifera), Vitamin C (Ascorbate).
Availability & where to buy
Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.
How it works: the HPA axis pathway →
Used in these protocols
Common questions
Does DSIP (Delta Sleep-Inducing Peptide, Emideltide) actually work?
Human-evidence rating: 2 of 5. Intriguing sleep/stress peptide; limited modern data.
Is DSIP (Delta Sleep-Inducing Peptide, Emideltide) legal or approved?
Regulatory status: Not Approved.