Citicoline (CDP-Choline)
Evidence: ★★★★☆ · Status: OTC Supplement
In plain English
Feeds your brain the raw materials to make its "memory and focus" chemical (acetylcholine) and to build cell membranes. Well-tolerated, decent evidence for attention.
How it works
Choline + cytidine → precursor for acetylcholine synthesis and for phosphatidylcholine (neuronal membranes); also raises dopamine receptor density. Prescription (Somazina) for stroke in some countries.
Molecular target & official sources
CHAT choline acetyltransferase (NCBI Gene) · Citicoline (PubChem CID 13804)
Protocol
250–500 mg/day.
Bottom line
One of the better-evidenced cholinergic nootropics.
Helps with: Focus & Cognition · Bone Health
Stacks with
Shares a pathway — often paired with: Caffeine, Modafinil / Armodafinil, Amphetamine (Adderall) / Lisdexamfetamine (Vyvanse), Methylphenidate (Ritalin).
Availability & where to buy
Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.
How it works: the Monoamines pathway →
Used in these protocols
Compare Citicoline (CDP-Choline)
- Citicoline (CDP-Choline) vs Caffeine
- Citicoline (CDP-Choline) vs Modafinil / Armodafinil
- Citicoline (CDP-Choline) vs Amphetamine (Adderall) / Lisdexamfetamine (Vyvanse)
- Citicoline (CDP-Choline) vs Methylphenidate (Ritalin)
- Citicoline (CDP-Choline) vs L-Theanine
- Citicoline (CDP-Choline) vs Tesamorelin (Egrifta)
- Citicoline (CDP-Choline) vs Bacopa Monnieri
- Citicoline (CDP-Choline) vs Vitamin D3 (+ K2)
Common questions
Does Citicoline (CDP-Choline) actually work?
Human-evidence rating: 4 of 5. One of the better-evidenced cholinergic nootropics.
How do you take Citicoline (CDP-Choline)?
250–500 mg/day.
Is Citicoline (CDP-Choline) legal or approved?
Regulatory status: OTC Supplement.