Acarbose

Evidence: ★★★☆☆ · Status: Off-Label, FDA Approved

💡 Did you know? Acarbose blocks the enzyme that digests starch, so some carbs pass through undigested — and it extended lifespan in mice, especially males.

In plain English

Blocks part of carb digestion so sugar trickles in instead of spiking — like a partial low-carb effect in a pill. One of the more reproducible lifespan-extenders in mice.

How it works

Inhibits intestinal α-glucosidase (MGAM/SI), slowing carbohydrate digestion and blunting post-meal glucose spikes — mimicking mild caloric restriction. Extended median lifespan in the NIA Interventions Testing Program, especially in males.

Molecular target & official sources

MGAM maltase-glucoamylase (NCBI Gene) · Acarbose (PubChem CID 41774)

Watch out

Gas/bloating (undigested carbs ferment).

Bottom line

Cheap, prescription, solid animal longevity data.

Helps with: Live Longer · Gut Health

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

Used in these protocols

Insulin Resistance

Common questions

Does Acarbose actually work?

Human-evidence rating: 3 of 5. Cheap, prescription, solid animal longevity data.

What are the risks or side effects of Acarbose?

Gas/bloating (undigested carbs ferment).

Is Acarbose legal or approved?

Regulatory status: Off-Label, FDA Approved.