Browse medicines
Some records contain detailed evidence; others currently contain only basic identity and regulatory information. Reviewed conclusions appear only when they are available for a specific use and group of people.
Showing 1–21 of 21 records
Psilocybin (COMP360 (COMPASS Pathways synthetic formulation); no marketed product)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. Tested for depression that has not responded to other treatments, and for depression and anxiety in people with cancer
Heroin (Diamorphine, Diacetylmorphine) (Diamorphine Hydrochloride for Injection — a licensed medicine in the United Kingdom. Originally marketed by Bayer as Heroin from 1898)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
In the UK, severe pain after surgery, during a heart attack, in terminal illness, and breathlessness in acute heart failure. In the US, nothing — it is in the schedule reserved for drugs with no accepted medical use
MDMA (3,4-Methylenedioxymethamphetamine) (Midomafetamine — the proposed non-proprietary name in NDA 215455. No marketed product)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. Two completed phase 3 trials tested it, with therapy, for post-traumatic stress disorder; the FDA turned the application down and asked for another trial
Melanotan II (No trade name; sold as MT-II or MT2, by injection and as a nasal spray)
Peptide medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Tanning without sun — unlicensed everywhere, with no approved use
LSD (Lysergic Acid Diethylamide) (Delysid (Sandoz, 1947-1966); MM120 / lysergide D-tartrate in current trials)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing, legally, in the United States — it is a Schedule I drug. It is being tested in late-stage trials for generalised anxiety disorder
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) (Sold briefly in Europe in the early 1990s as Nexus, Erox and Performax before scheduling; no approved product)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. It is a Schedule I phenethylamine that has just become the subject of controlled brain-imaging research because its effects differ from psilocybin's in ways researchers want to understand
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) (GH001, a vaporised synthetic formulation in clinical development; the INN assigned to the molecule is mebufotenin)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. A synthetic inhaled version is in trials for depression that has not responded to other drugs; the substance itself is Schedule I
Ibogaine (No marketed product. Historically sold in France as Lambarène, a Tabernanthe extract tonic, until 1966)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. People travel to clinics outside the United States to take it for opioid withdrawal, and the published observational studies of those clinics are the entire clinical evidence base
JWH-018 and the Synthetic Cannabinoid Class (K2 / Spice) (Sold as herbal incense under hundreds of brand names — Spice, K2, AK-47 24 Karat Gold, Scooby Snax — never under a chemical name)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. These are laboratory research chemicals sprayed onto plant matter and sold as incense, and the compounds in them change faster than the law can list them
Psilocin (4-Hydroxy-N,N-dimethyltryptamine) (No product. It is the active metabolite of psilocybin, which is the compound formulated in every clinical trial)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. It is the molecule that psilocybin turns into in the body, and it is the one that does the work — every psilocybin trial result on this site is really a psilocin result
Boldenone (Equipoise, Boldebal, Ganabol; sold as boldenone undecylenate ("EQ"))
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
A horse steroid used by people — no human approval anywhere
DMT (N,N-Dimethyltryptamine) (No marketed product. The principal psychoactive constituent of ayahuasca; SPL026 and similar synthetic DMT fumarate formulations are in clinical trials)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. A single randomised trial of ayahuasca in 29 people with depression that had not responded to other treatments
Nitazenes (Isotonitazene and the 2-Benzylbenzimidazole Opioids) (None. Never marketed as a medicine anywhere. Sold in the illicit supply as counterfeit tablets, in heroin substitutes and as powder)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. These are 1950s analgesic candidates that were never developed, resurfacing sixty years later in the illicit drug supply because they are easy to make and are not on the lists
Cannabis (Plant Preparation) (Sold as flower, resin, concentrate and edible. Isolated delta-9-THC and cannabidiol have their own records on this site)
Nutritional or plant productControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved as a plant. Used under state medical-cannabis programmes for chronic pain, chemotherapy nausea and multiple sclerosis spasticity, where the trial evidence is for isolated or standardised cannabinoids rather than for smoked flower
Clenbuterol (Ventipulmin (veterinary, United States); Spiropent, Broncoterol and others abroad)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
A horse asthma drug in the United States, taken by people for fat loss
Delta-8-Tetrahydrocannabinol (No approved product. Sold as vape cartridges, gummies, tinctures and pre-rolls in petrol stations, smoke shops and online)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing approved. It is a legal-in-most-states intoxicant made by chemically converting CBD, and children under six accounted for 30.1% of the poison-centre cases
Mescaline (No marketed product. The principal alkaloid of peyote (Lophophora williamsii) and San Pedro (Trichocereus / Echinopsis species))
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. Mescaline is the only classic psychedelic in this group with no modern randomised trial at all
PCP (Phencyclidine) (Sernyl — marketed by Parke-Davis as a human anaesthetic from the late 1950s and withdrawn from human use in the mid-1960s; Sernylan, the veterinary formulation, was withdrawn in 1978)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. It was an anaesthetic that worked but left patients delirious for hours afterwards, and it became the drug that taught psychiatry what schizophrenia might be a disorder of
Trenbolone (Approved in the United States only for cattle, as trenbolone acetate implants (Finaplix, and in combination products such as Revalor and Synovex Plus))
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
None in people. It is a cattle growth implant and a controlled substance
Mephedrone (4-Methylmethcathinone) (Sold openly in the United Kingdom in 2009 and 2010 as "plant food" and "bath salts", labelled not for human consumption. No approved product)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. It was sold legally across the UK for about eighteen months, banned in 2010, and is now the best-studied of the synthetic cathinones
Salvinorin A (Salvia divinorum) (No product. Sold as dried leaf and as "fortified" leaf extracts of stated multiples)
Small chemical medicineControlled substance; no approved US useDetailed recordUse listed on the medicine record
Nothing. It is a research tool that became a recreational drug, and in the United States its legal status depends entirely on which state you are standing in