SLC6A3
SLC6A3 dopamine transporter — the molecular target that 3 compounds in the wiki act on.
In one line: The "vacuum cleaner" that clears dopamine — blocked by stimulants for focus.
SLC6A3 is the dopamine transporter — think of it as a tiny vacuum cleaner that sucks the motivation-and-reward chemical dopamine back up after a nerve fires, ending the signal. Focus drugs work by blocking this vacuum, so dopamine lingers longer and the "get-up-and-go" signal stays switched on.
Modafinil blocks it gently (clean, sustained alertness). ADHD stimulants like Adderall block it hard and force out more dopamine (powerful focus — and real addiction risk). This is the machinery behind almost every strong focus drug.
The catch with the strong ones: flood dopamine too hard, too often, and the brain compensates by turning down its own supply — that's tolerance and dependence. Gentler is more sustainable.