HCRT
HCRT orexin — the molecular target that 1 compounds in the wiki act on.
In one line: Your brain's "stay awake" signal — the orexin system.
HCRT (orexin) is the brain chemical that keeps you awake and alert; losing the cells that make it causes narcolepsy. Wakefulness drugs like modafinil partly work by boosting this "stay awake" system.
Its opposite is just as useful: the newest sleep drugs (orexin blockers) switch this system off to let you sleep — a cleaner approach than older sedatives, because it removes the "awake" signal rather than force-sedating the whole brain.