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ESR2

ESR2 estrogen receptor beta — the molecular target that 1 compounds in the wiki act on.

In one line: A second oestrogen receptor that plant "ecdysteroids" may work through — non-hormonally.

ESR2 (oestrogen receptor beta) is a cousin of the main oestrogen receptor, but activating it doesn't cause typical hormonal (feminising) effects. It's the proposed route for ecdysterone — the plant compound behind "natural anabolic" hype — which may nudge muscle protein synthesis through this receptor rather than through testosterone.

The evidence is thin (one suggestive human study for ecdysterone; almost none for turkesterone), so temper expectations. It's not working like a steroid.

Compounds acting on ESR2