ABL1
ABL1 — the molecular target that 1 compounds in the wiki act on.
In one line: A "grow" switch inside certain cells that a leukaemia drug shuts off — also used to kill ageing "zombie" cells.
ABL1 is a signalling enzyme that, when stuck on, drives cells to grow — a known cause of one type of leukaemia. The cancer drug dasatinib blocks it. In longevity research, dasatinib is repurposed (paired with quercetin) as a senolytic — it helps clear "zombie" cells that refuse to die and leak inflammation. Because it's a real chemotherapy drug, this belongs strictly under medical supervision, not DIY.