LL-37 vs Rapamycin (Sirolimus)
Both are used for immunity. Here's how they compare on human evidence, mechanism, safety and availability — in plain English.
| LL-37 | Rapamycin (Sirolimus) | |
|---|---|---|
| Human evidence | ★★☆☆☆ | ★★★★★ |
| Legal status | Not Approved | Off-Label, FDA Approved |
| How it works | Human cathelicidin (CAMP gene) antimicrobial peptide; disrupts microbial membranes and modulates immunity/wound healing. | Binds FKBP12 to inhibit mTOR complex 1 — flipping cells from growth to maintenance (autophagy, stress resistance, less senescence). What mTOR is and why dialling it down matters → the mTOR pathway. The compound-specific nuance is… |
| In plain English | A natural antibiotic your own body makes; explored for infections and healing. Very early for supplemental use. | Rapamycin dials the "grow" switch (mTOR) down periodically, flipping cells into "clean and repair." It extends lifespan in every animal tested — the single most reliable longevity drug — but human data is still coming in. Taken weekly, not… |
| Bottom line | Interesting antimicrobial biology; minimal human supplement data. | The most compelling longevity drug we have; still needs human RCTs (PEARL, others ongoing). |
| Availability | Not widely approved | Prescription only |
Which is better for immunity?
Rapamycin (Sirolimus) has the stronger human-evidence rating (★★★★★ vs ★★☆☆☆), but the right choice still depends on your goal, tolerance and budget.
Full breakdowns: LL-37 · Rapamycin (Sirolimus).
Common questions
Is LL-37 or Rapamycin (Sirolimus) better for immunity?
Rapamycin (Sirolimus) has the stronger human-evidence rating (★★★★★ vs ★★☆☆☆), but the right choice still depends on your goal, tolerance and budget.
What's the difference between LL-37 and Rapamycin (Sirolimus)?
LL-37: Interesting antimicrobial biology; minimal human supplement data. — Rapamycin (Sirolimus): The most compelling longevity drug we have; still needs human RCTs (PEARL, others ongoing).