Setmelanotide (Imcivree)

Evidence: ★★★★☆ · Status: FDA Approved

In plain English

For people whose "I'm full" brain switch is broken by a specific gene defect, this presses it directly. Approved but niche.

How it works

MC4R (melanocortin-4 receptor) agonist; restores the central satiety signal in rare genetic obesity (POMC/LEPR deficiency).

Molecular target & official sources

MC4R (NCBI Gene) · Setmelanotide (PubChem CID 92131875)

Bottom line

Precision drug for monogenic obesity.

Helps with: Lose Fat

Stacks with

Shares a pathway — often paired with: PT-141 (Bremelanotide / Vyleesi), KPV, Melanotan II.

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the Melanocortin pathway →