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Lion's Mane (Hericium erinaceus)

Evidence: ★★★☆☆ · Status: OTC Supplement

💡 Did you know? Lion's mane mushroom stimulates nerve growth factor — proteins that help brain and nerve cells grow and repair.

In plain English

A mushroom that nudges your brain to produce more "nerve fertiliser" (NGF), supporting new connections over months. Buy fruiting-body extract, not grain filler.

How it works

Hericenones/erinacines stimulate Nerve Growth Factor (NGF) synthesis, supporting neurogenesis and myelination (long-term, not acute).

Molecular target & official sources

NGF nerve growth factor (NCBI Gene) · Examine: Lion's Mane

Protocol

500–3,000 mg/day extract.

Bottom line

Promising, long-horizon; product quality varies hugely.

Helps with: Focus & Cognition

Stacks with

Shares a pathway — often paired with: EPO (Erythropoietin), Tesamorelin (Egrifta), Human Growth Hormone (Somatropin), Insulin (anabolic misuse).

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

How it works: the PI3K/Akt growth factor pathway →

Used in these protocols

Common questions

Does Lion's Mane (Hericium erinaceus) actually work?

Human-evidence rating: 3 of 5. Promising, long-horizon; product quality varies hugely.

How do you take Lion's Mane (Hericium erinaceus)?

500–3,000 mg/day extract.

Is Lion's Mane (Hericium erinaceus) legal or approved?

Regulatory status: OTC Supplement.