Ligandrol (LGD-4033)
Evidence: ★★★☆☆ · Status: Not Approved
In plain English
One of the strongest SARMs for size — and correspondingly strong at shutting down your natural testosterone. Liver-injury reports exist.
How it works
High-affinity, high-potency AR agonist (>500:1 anabolic:androgenic in models), strong muscle selectivity, oral.
Molecular target & official sources
AR (NCBI Gene) · LGD-4033 (PubChem CID 44137675)
Watch out
Marked suppression, hepatotoxicity.
Helps with: Build Muscle & Strength · Hormones & Testosterone
Stacks with
Shares a pathway — often paired with: Omega-3 (EPA/DHA), Vitamin D3 (+ K2), Testosterone (TRT), Finasteride / Dutasteride.
Availability & where to buy
Not widely approved. Not approved for general sale in most markets (Singapore included). Grey-market only — dose, purity and legality uncertain.
How it works: the Nuclear receptors pathway →
Common questions
Does Ligandrol (LGD-4033) actually work?
Human-evidence rating: 3 of 5. One of the strongest SARMs for size — and correspondingly strong at shutting down your natural testosterone. Liver-injury reports exist.
What are the risks or side effects of Ligandrol (LGD-4033)?
Marked suppression, hepatotoxicity.
Is Ligandrol (LGD-4033) legal or approved?
Regulatory status: Not Approved.