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HCG (Human Chorionic Gonadotropin)

Evidence: ★★★★☆ · Status: Prescription

💡 Did you know? HCG mimics the brain's LH signal — which is why it's used to keep the testes working, and fertility intact, while on testosterone.

In plain English

TRT tells the testicles to switch off, so they shrink and fertility drops. HCG impersonates the brain's "keep working" signal so they stay online.

How it works

Mimics luteinising hormone (LH) at the LHCGR receptor on testicular Leydig cells, driving intratesticular testosterone and sperm production — bypassing the pituitary shutdown that TRT causes.

Molecular target & official sources

LHCGR LH/hCG receptor (NCBI Gene) · Choriogonadotropin (PubChem)

Bottom line

Standard companion to TRT for men wanting to preserve fertility/size.

Helps with: Hormones & Testosterone

Stacks with

Shares a pathway — often paired with: Omega-3 (EPA/DHA), Vitamin D3 (+ K2), Testosterone (TRT), Finasteride / Dutasteride.

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

How it works: the Nuclear receptors pathway →

Used in these protocols

Low Testosterone

Common questions

Does HCG (Human Chorionic Gonadotropin) actually work?

Human-evidence rating: 4 of 5. Standard companion to TRT for men wanting to preserve fertility/size.

Is HCG (Human Chorionic Gonadotropin) legal or approved?

Regulatory status: Prescription.