Ca-AKG (Calcium Alpha-Ketoglutarate)
Evidence: ★★☆☆☆ · Status: OTC Supplement
In plain English
A cellular-energy molecule that also helps reset the chemical "tags" on your DNA that drift with age. A small human study showed reduced biological age; more needed.
How it works
TCA-cycle intermediate and cofactor for TET enzymes / DNA-demethylases and prolyl hydroxylases — influences the epigenetic "aging clock." Reduced frailty and biological age markers in a small human study (TruDiagnostic/Ponce de Leon).
Molecular target & official sources
Alpha-ketoglutarate (PubChem CID 51) · TET2 (NCBI Gene)
Protocol
1,000 mg/day.
Bottom line
Promising epigenetic-aging candidate; early human data.
Helps with: Live Longer
Availability & where to buy
Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.
Used in these protocols
Common questions
Does Ca-AKG (Calcium Alpha-Ketoglutarate) actually work?
Human-evidence rating: 2 of 5. Promising epigenetic-aging candidate; early human data.
How do you take Ca-AKG (Calcium Alpha-Ketoglutarate)?
1,000 mg/day.
Is Ca-AKG (Calcium Alpha-Ketoglutarate) legal or approved?
Regulatory status: OTC Supplement.