B-Complex / B12 / Methylfolate / B6

Evidence: ★★★★☆ · Status: OTC Supplement

In plain English

The spark plugs of energy metabolism and the "methylation" chemistry that runs DNA, mood, and detox. Use methylfolate/methyl-B12 (active forms) especially if you have an MTHFR gene variant.

How it works

Coenzymes in one-carbon metabolism and methylation (MTHFR converts folate to active 5-MTHF), homocysteine clearance, energy metabolism, and neurotransmitter synthesis. B12 (methylcobalamin) is depleted by metformin and in vegans.

Molecular target & official sources

MTHFR (NCBI Gene) · Methylcobalamin (PubChem CID 6436231)

Bottom line

Correct deficiency (vegans, metformin users); methylated forms preferred.

Helps with: Stress & Anxiety

Availability & where to buy

Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.

Used in these protocols

• Chronic Fatigue / Low Energy