17-α-Estradiol

Evidence: ★★☆☆☆ · Status: Off-Label

In plain English

A "mirror-image" estrogen that helped male mice live longer without female side effects. Male-specific and still experimental.

How it works

Weak, non-feminising estrogen stereoisomer; extended male mouse lifespan in the ITP without feminisation — likely via hypothalamic inflammation/metabolic effects rather than classic ER signalling.

Molecular target & official sources

ESR1 (NCBI Gene) · 17-alpha-estradiol (PubChem CID 68151)

Bottom line

Curious male-specific longevity signal; human use investigational.

Helps with: Recover Faster · Live Longer · Hormones & Testosterone

Stacks with

Shares a pathway — often paired with: Omega-3 (EPA/DHA), Vitamin D3 (+ K2), Testosterone (TRT), Finasteride / Dutasteride.

Availability & where to buy

Prescription only. Prescription-only — a doctor must prescribe it. Not sold over the counter. (In Singapore: HSA-regulated.)

How it works: the Nuclear receptors pathway →