SLC6A2
SLC6A2 norepinephrine transporter — the molecular target that 1 compounds in the wiki act on.
In one line: The vacuum cleaner for noradrenaline — blocked to raise alertness and curb appetite.
SLC6A2 is the transporter that clears noradrenaline, an alertness-and-arousal chemical. Blocking it keeps noradrenaline around longer — raising focus and suppressing appetite. Some ADHD medicines and the older weight drug phentermine work partly this way.
It's the "stay alert" counterpart to the dopamine vacuum, and a reason certain focus and appetite drugs overlap.