RARA
RARA retinoic acid receptor — the molecular target that 1 compounds in the wiki act on.
In one line: The vitamin-A receptor that retinoids use to renew skin and build collagen.
RARA (a retinoic acid receptor) is how vitamin-A-based skincare (retinoids like tretinoin) works. Activating it speeds up skin-cell renewal and switches on collagen production — which is why retinoids are the single most proven ingredient for wrinkles and acne.
Everything else in skincare is secondary to this. The trade-off is irritation early on, so you introduce it slowly.