PCSK9
PCSK9 — the molecular target that 1 compounds in the wiki act on.
In one line: A protein that destroys your "bad-cholesterol vacuum cleaners" — blocking it slashes LDL.
Your liver has receptors that act like vacuum cleaners, pulling bad (LDL) cholesterol out of your blood. PCSK9 is a protein that destroys those vacuums. Newer heart drugs block PCSK9 so the vacuums survive longer and clear far more LDL — dropping it dramatically. One version (inclisiran) silences PCSK9 with an injection needed only twice a year.
It's one of the most powerful cholesterol-lowering tools ever made, used when statins aren't enough.