OPRM1
OPRM1 mu-opioid receptor — the molecular target that 1 compounds in the wiki act on.
In one line: The main opioid receptor — blocking it curbs cravings and reward-eating.
OPRM1 (the mu-opioid receptor) handles reward and pleasure — including from food. The weight drug Contrave pairs a blocker of this receptor with an appetite-suppressant, which together dampen cravings and reward-driven eating. So it targets why people overeat (reward) rather than gut fullness — useful for emotional or craving-led eating.
Blocking the reward receptor takes some of the "pull" out of tempting food.