INSR
INSR insulin receptor — the molecular target that 1 compounds in the wiki act on.
In one line: The receptor that lets insulin push nutrients into your cells.
The insulin receptor is the gateway insulin uses to move sugar and amino acids out of your blood and into your cells. After a meal, insulin docks here and tells cells to take up fuel — storing energy and, in muscle, driving growth.
This makes insulin one of the most powerfully anabolic (muscle-building) signals in the body. It's also why insulin is so dangerous when misused for physique: push too much and blood sugar can crash into a coma. It's among the highest-risk substances misused in the gym.
"Insulin sensitivity" — how well this receptor responds — is central to metabolic health. Exercise, sleep, and drugs like metformin all improve it; constant overeating dulls it.