HCRTR2
HCRTR2 orexin receptor 2 — the molecular target that 1 compounds in the wiki act on.
In one line: The "stay awake" receptor — blocking it is how modern sleep drugs work.
HCRTR2 is one of the receptors the wake-promoting orexin signal acts on. The newest prescription sleep drugs (suvorexant, lemborexant) block it — quietly switching off the brain's "stay awake" command so natural sleep can take over.
This is gentler than older sleeping pills that hammer the brain's brake and cause grogginess and dependence. Here you're just letting the wakefulness signal fade, so sleep architecture stays more natural.