GLP1R
GLP1R glucagon-like peptide 1 receptor — the molecular target that 5 compounds in the wiki act on.
In one line: The gut-and-brain "I'm full" receptor that the new weight-loss drugs switch on.
The GLP-1 receptor normally responds to a hormone your gut releases after eating. When it's activated, it does several helpful things at once: tells your brain you're full, slows how fast your stomach empties (so you stay full longer), and helps your pancreas manage blood sugar.
The blockbuster weight-loss drugs — semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) — are copies of that gut hormone that switch this receptor on powerfully and for a whole week per dose. The result is a dramatic drop in hunger and "food noise," and 15–22% body-weight loss in trials.
The important catch: these drugs cause muscle loss alongside fat loss, so resistance training and high protein aren't optional extras — they're what keep the weight you lose from being muscle.