GIPR
GIPR gastric inhibitory polypeptide receptor — the molecular target that 2 compounds in the wiki act on.
In one line: A second gut "fullness" receptor that the newest weight-loss drugs hit alongside GLP-1.
GIPR responds to another gut hormone (called GIP) that helps manage blood sugar and appetite. On its own it's modest, but paired with the GLP-1 receptor it becomes powerful — which is exactly what tirzepatide (Mounjaro/Zepbound) does: it presses both "fullness" receptors at once, producing even greater weight loss than hitting GLP-1 alone.
Think of it as a second dimmer switch for hunger. One switch helps; turning down both together helps a lot more — which is why the dual drugs outperform the single ones.