GCGR
GCGR glucagon receptor — the molecular target that 1 compounds in the wiki act on.
In one line: The glucagon receptor — the third switch in the most powerful weight-loss drug in trials.
GCGR responds to glucagon, a hormone that raises energy expenditure and tells the liver to burn fat. On its own that's not a diet tool, but the experimental drug retatrutide adds glucagon-receptor activation on top of the two "fullness" receptors (GLP-1 and GIP) — so it cuts hunger and turns up calorie-burning at once. That triple action produced the largest weight loss ever recorded for a drug (about 24% of body weight).
Think of it as the "burn more" switch added to the "eat less" switches.