EP300
EP300 — the molecular target that 1 compounds in the wiki act on.
In one line: A brake on cellular "self-cleaning" that spermidine releases to slow ageing.
EP300 normally holds back autophagy — your cells' recycling-and-cleanup program. The longevity compound spermidine works partly by blocking EP300, which lets autophagy switch on so cells clear out damaged parts, much as fasting does. Populations who eat more spermidine (from wheat germ and aged cheese) tend to live longer.
Think of it as taking your foot off the brake so the cell's cleanup crew can get to work.