DIO2
DIO2 deiodinase — the molecular target that 1 compounds in the wiki act on.
In one line: The enzyme that switches thyroid hormone into its active form — your metabolism's activator.
DIO2 converts the storage form of thyroid hormone (T4) into the active form (T3) that actually revs up your metabolism. It needs the mineral selenium to work. Your thyroid is the body's metabolic thermostat, built from iodine and switched on by selenium — which is why both minerals matter for energy and metabolism.
If this conversion runs poorly, you can feel sluggish even with "normal" thyroid levels, because the active hormone isn't being made.