CALCR
CALCR calcitonin/amylin receptor — the molecular target that 1 compounds in the wiki act on.
In one line: The receptor for amylin, a second "I'm full" hormone stacked with GLP-1 drugs.
CALCR (the calcitonin/amylin receptor) responds to amylin, a hormone that works alongside insulin to slow digestion and signal fullness. It's a different fullness pathway from GLP-1 — which is why the newest experimental combos (cagrilintide plus semaglutide) stack them: two separate "I'm full" systems switched on together for greater appetite control.
Think of it as a second, independent hunger dimmer. Turning down two different ones at once beats leaning on just one.