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Public dataset

Recorded source agreement and disagreement

Show whether sources print one normalized reading, have incompatible units, lack structured comparison context, or contain a context-matched numeric difference.

What this does not mean: agree can mean only that sources print the same normalized reading; it is not clinical-context equivalence, independent replication, or proof. differ requires matching structured context and disjoint comparable values. not_comparable and insufficient_context are not disagreement.
Public rows
1,681
Generated
Schema version
source-consensus/2

Coverage

What this run contains

Compared medicine fields
1,681
Agree
1,282
Differ
0
Not comparable
12
Insufficient context
387
Fields represented
5
bioavailability, halfLife, proteinBinding, tMax, volumeOfDistribution

Method

How the rows were made

  1. Deterministic rules normalize recorded pharmacokinetic readings and compare only like-for-like values.
  2. One normalized printed reading may be agree even when clinical context was not extracted; this reports printed-reading agreement only.
  3. Distinct readings may differ only when their units and denominators are comparable and one matching, non-placeholder population/formulation context was structurally extracted. Otherwise they are insufficient_context.
  4. not_comparable preserves incompatible units or denominators instead of guessing. insufficient_context preserves missing or non-matching structured context instead of manufacturing agreement or disagreement.
  5. The agreement rate describes the distribution of recorded source readings; it is not a probability that a value is true.
  6. Every distinct printed reading retains its unit, population context, source count, and complete source records. The API paginates field rows, never child readings or sources.
  7. documentsExamined is every matching single-substance archive document inspected for that medicine. The generator has no document, reading, or source ceiling, so there is no hidden available-versus-retained remainder.

Limits

Read these before using a row

  • Current label parsing does not structurally extract population or formulation context. Distinct otherwise-comparable readings are therefore insufficient_context, never differ; agree may mean printed-reading agreement only. Source records are complete but are not independent-experiment counts.
  • The current deterministic parser does not structurally extract population or formulation context from these sentences. It records that context as unknown and cannot publish distinct same-unit readings as differ.
  • Neither reading is marked wrong. Population, formulation, route, and other unextracted context may explain the printed difference.
  • Only the recorded fields and source documents in this snapshot are compared.
  • A source count is the number of retained source records in the row, not a count of independent experiments.

Provenance

Source examples

abacavir · bioavailability · agree

15 documents examined; 83% (Unknown: population and formulation context were not structurally extracted from this source sentence.)

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
The geometric mean absolute bioavailability of the tablet was 83%.

alemtuzumab · volumeOfDistribution · not_comparable

2 documents examined; 0.18 L/kg (Unknown: population and formulation context were not structurally extracted from this source sentence.); 14.1 L (Unknown: population and formulation context were not structurally extracted from this source sentence.)

FDA_LABEL:4f5f7255-7abc-4328-bd1a-ceaf139ef3e0 (opens source in a new tab)
Distribution After the last 30 mg dose, the mean volume of distribution at steady-state was 0.18 L/kg (range 0.1 to 0.4 L/kg).

abiraterone · halfLife · insufficient_context

31 documents examined; 12 ± 5 hours (Unknown: population and formulation context were not structurally extracted from this source sentence.); 18 hours (Unknown: population and formulation context were not structurally extracted from this source sentence.)

FDA_LABEL:c9eb9b46-f847-40a8-802c-a51b40406d5a (opens source in a new tab)
Elimination In patients with metastatic CRPC, the mean terminal half-life of abiraterone in plasma (mean ± SD) is 12 ± 5 hours.

Artifact used for this view: data/source-consensus.ndjson. The reader resolves the current run first and uses the checked-in compatibility run only when a current artifact is absent.

Schema

Fields in the public projection

FieldTypeMeaning
medicineSlugstringStable RNAWiki medicine route key.
fieldstringRecorded pharmacokinetic field being compared.
comparisonStatestringagree (printed-reading agreement), differ (context-matched comparable disjoint values), not_comparable (unit/denominator mismatch), or insufficient_context. Every state remains declared even when its current count is zero.
comparisonReasonsstring[]Deterministic codes explaining the state.
documentsExaminednumberRecorded source documents considered for the field.
sourceCountnumberRecorded source readings represented.
agreementRatenumberShare represented by the leading normalized printed-reading group; not a confidence score or clinical agreement probability.
readingsconsensus-reading[]Complete, untruncated reading groups. Each keeps the printed display, numeric value when parsed, unit, population context, source count, and every source identity, version/effective date or explicit absence, retrieval date, locator, safe link, and excerpt.

Reader

Search and filter the rows

Case-insensitive text search over the public fields named for this dataset.

Exact comparability state.

Exact recorded field key.

Clear

Showing 791800 of 1,681 matching rows. Filters and search terms remain attached when you move between pages or open the API view.

  1. Projected row 791

    Medicine slug
    isradipine
    Compared field
    tMax
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    3
    Source count
    3
    Agreement rate
    1
    Recorded readings
    1. 1.5 hours

      Numeric value
      1.5
      Unit
      hours
      Source records
      3

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 3 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:bf3425e0-428d-4bdb-ac9a-3b9d483df83a (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        Isradipine is detectable in plasma within 20 minutes after administration of single oral doses of 2.5 to 20 mg, and peak concentrations of approximately 1 ng/mL/mg dosed occur about 1.5 hours after drug administration.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:acf7c376-6cb6-4857-b455-0bf5da29346c (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        Isradipine is detectable in plasma within 20 minutes after administration of single oral doses of 2.5 to 20 mg, and peak concentrations of approximately 1 ng/mL/mg dosed occur about 1.5 hours after drug administration.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:fdb4c50e-6e6f-a43d-e053-6294a90aa24f (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        Isradipine is detectable in plasma within 20 minutes after administration of single oral doses of 2.5-20 mg, and peak concentrations of approximately 1 ng/mL/mg dosed occur about 1.5 hours after drug administration.
  2. Projected row 792

    Medicine slug
    isradipine
    Compared field
    volumeOfDistribution
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    3
    Source count
    3
    Agreement rate
    1
    Recorded readings
    1. 3 L/kg

      Numeric value
      3
      Unit
      L/kg
      Source records
      3

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 3 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:bf3425e0-428d-4bdb-ac9a-3b9d483df83a (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        The total body clearance of isradipine is 1.4 L/min and the apparent volume of distribution is 3 L/kg.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:acf7c376-6cb6-4857-b455-0bf5da29346c (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        The total body clearance of isradipine is 1.4 L/min and the apparent volume of distribution is 3 L/kg.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:fdb4c50e-6e6f-a43d-e053-6294a90aa24f (opens source in a new tab)

        Isradipine label

        Version not recorded · Effective date not recorded

        The total body clearance of isradipine is 1.4 L/min and the apparent volume of distribution is 3 L/kg.
  3. Projected row 793

    Medicine slug
    itraconazole
    Compared field
    bioavailability
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    15
    Source count
    14
    Agreement rate
    1
    Recorded readings
    1. 55%

      Numeric value
      55
      Unit
      %
      Source records
      14

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 14 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6df5ff94-47ba-4881-abb4-b321e35a6955 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:68165d90-953c-e2f5-e053-2a91aa0ada25 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:46732a10-1f0d-4022-9689-256c44683e96 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:5af0b33d-bfa6-420b-86f0-067f95b402b2 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute bioavailability of itraconazole under fed conditions is about 55% and increases by 30% when the oral solution is taken in fasting conditions.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:da63870d-b426-4e49-9591-5bb51f962e66 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute bioavailability of itraconazole under fed conditions is about 55% and increases by 30% when the oral solution is taken in fasting conditions.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2ab38a8a-3708-4b97-9f7f-8e554a15348d (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:b1274d78-1096-4ae3-8299-a2e94eaa0ea5 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:f9d8b5a7-435f-40e6-8596-5f2376b92c74 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e564067e-e469-4c51-9076-75f89f5c5cdf (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6242b7ad-eaa0-a524-b6e0-ec33e63407db (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:349ffcf4-b2cd-4c93-9411-13c39275b8f3 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      12. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:a4d555fa-787c-40fb-bb7d-b0d4f7318fd0 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      13. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:23126370-8d6a-4027-bd8f-860e2776ba3a (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute oral bioavailability of itraconazole is about 55%.
      14. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:43ded1aa-f825-40fe-aa9a-addd36a07f06 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The observed absolute bioavailability of itraconazole under fed conditions is about 55% and increases by 30% when the oral solution is taken in fasting conditions.
  4. Projected row 794

    Medicine slug
    itraconazole
    Compared field
    halfLife
    Comparison state
    insufficient_context
    Reason codes
    • STRUCTURED_CONTEXT_MISSING
    Documents examined
    15
    Source count
    15
    Agreement rate
    0.933333
    Recorded readings
    1. 16 to 28 hours

      Numeric value
      16
      Unit
      hours
      Source records
      14

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 14 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6df5ff94-47ba-4881-abb4-b321e35a6955 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:68165d90-953c-e2f5-e053-2a91aa0ada25 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:46732a10-1f0d-4022-9689-256c44683e96 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:5af0b33d-bfa6-420b-86f0-067f95b402b2 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:da63870d-b426-4e49-9591-5bb51f962e66 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2ab38a8a-3708-4b97-9f7f-8e554a15348d (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:b1274d78-1096-4ae3-8299-a2e94eaa0ea5 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:f9d8b5a7-435f-40e6-8596-5f2376b92c74 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e564067e-e469-4c51-9076-75f89f5c5cdf (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6242b7ad-eaa0-a524-b6e0-ec33e63407db (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:349ffcf4-b2cd-4c93-9411-13c39275b8f3 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      12. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:a4d555fa-787c-40fb-bb7d-b0d4f7318fd0 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      13. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:23126370-8d6a-4027-bd8f-860e2776ba3a (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
      14. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:43ded1aa-f825-40fe-aa9a-addd36a07f06 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
    2. 37 ± 17 hours

      Numeric value
      37
      Unit
      hours
      Source records
      1

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 1 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:306352d1-9d5a-49ad-b72d-893b99546861 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        A statistically significant reduction in mean C max (47%) and a twofold increase in the elimination half-life (37 ± 17 hours vs. 16 ± 5 hours) of itraconazole were noted in cirrhotic subjects compared with healthy subjects.
  5. Projected row 795

    Medicine slug
    itraconazole
    Compared field
    tMax
    Comparison state
    insufficient_context
    Reason codes
    • STRUCTURED_CONTEXT_MISSING
    Documents examined
    15
    Source count
    15
    Agreement rate
    0.733333
    Recorded readings
    1. 2 to 5 hours

      Numeric value
      2
      Unit
      hours
      Source records
      11

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 11 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6df5ff94-47ba-4881-abb4-b321e35a6955 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:68165d90-953c-e2f5-e053-2a91aa0ada25 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:46732a10-1f0d-4022-9689-256c44683e96 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2ab38a8a-3708-4b97-9f7f-8e554a15348d (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:b1274d78-1096-4ae3-8299-a2e94eaa0ea5 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:f9d8b5a7-435f-40e6-8596-5f2376b92c74 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e564067e-e469-4c51-9076-75f89f5c5cdf (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6242b7ad-eaa0-a524-b6e0-ec33e63407db (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        Pharmacokinetics and Metabolism General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:349ffcf4-b2cd-4c93-9411-13c39275b8f3 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:a4d555fa-787c-40fb-bb7d-b0d4f7318fd0 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        Pharmacokinetics and Metabolism General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:23126370-8d6a-4027-bd8f-860e2776ba3a (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration.
    2. 2.5 hours

      Numeric value
      2.5
      Unit
      hours
      Source records
      3

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 3 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:5af0b33d-bfa6-420b-86f0-067f95b402b2 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        CLINICAL PHARMACOLOGY Pharmacokinetics and Metabolism: Itraconazole General Pharmacokinetic Characteristics Peak plasma concentrations are reached within 2.5 hours following administration of the oral solution.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:da63870d-b426-4e49-9591-5bb51f962e66 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        Pharmacokinetics and Metabolism: Itraconazole General Pharmacokinetic Characteristics Peak plasma concentrations are reached within 2.5 hours following administration of the oral solution.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:43ded1aa-f825-40fe-aa9a-addd36a07f06 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        Pharmacokinetics and Metabolism: Itraconazole General Pharmacokinetic Characteristics Peak plasma concentrations are reached within 2.5 hours following administration of the oral solution.
    3. 2 to 6 hours

      Numeric value
      2
      Unit
      hours
      Source records
      1

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 1 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:306352d1-9d5a-49ad-b72d-893b99546861 (opens source in a new tab)

        Itraconazole label

        Version not recorded · Effective date not recorded

        (hr*mcg/ml) 15.6 ± 3.7 14.9 ±3.8 C trough (mcg/ml) 1.2 ±0.4 1.0±0.3 C max,ss (mcg/ml) 1.6 ±0.4 1.5 ±0.4 T max,ss (h) 7.0 (1-10) 5.0 (1-8) Peak plasma concentrations of itraconazole after administration of a single dose of TOLSURA are reached within 2 to 6 hours following oral administration in either the fasted or fed states.
  6. Projected row 796

    Medicine slug
    ivabradine
    Compared field
    bioavailability
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    11
    Source count
    11
    Agreement rate
    1
    Recorded readings
    1. 40%

      Numeric value
      40
      Unit
      %
      Source records
      11

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 11 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2e70f883-8c01-4ac2-815d-4a6d561c711a (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:53f15531-796d-442b-a73c-05f048218531 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:236cc914-7eef-600c-e063-6394a90a4bd1 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:92018a65-38f6-45f7-91d4-a34921b81d0d (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:51ac7345-3188-4382-ab1d-9120d6c88927 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e881a1ac-9221-4682-939f-966679cfe286 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2ead1cf3-e61a-49c4-e063-6294a90a330f (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:602d1c55-0e4d-452a-a087-888fdbaa7568 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:676907d3-b374-4baa-8422-c04706409540 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:89134202-971b-4413-a9c9-d31a5c29722b (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:5157767b-16d5-4a69-b6bd-95d360d19fda (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        The absolute oral bioavailability of ivabradine is approximately 40% because of first-pass elimination in the gut and liver.
  7. Projected row 797

    Medicine slug
    ivabradine
    Compared field
    volumeOfDistribution
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    11
    Source count
    11
    Agreement rate
    1
    Recorded readings
    1. 100 L

      Numeric value
      100
      Unit
      L
      Source records
      11

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 11 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2e70f883-8c01-4ac2-815d-4a6d561c711a (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:53f15531-796d-442b-a73c-05f048218531 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:236cc914-7eef-600c-e063-6394a90a4bd1 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:92018a65-38f6-45f7-91d4-a34921b81d0d (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:51ac7345-3188-4382-ab1d-9120d6c88927 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e881a1ac-9221-4682-939f-966679cfe286 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2ead1cf3-e61a-49c4-e063-6294a90a330f (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:602d1c55-0e4d-452a-a087-888fdbaa7568 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:676907d3-b374-4baa-8422-c04706409540 (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:89134202-971b-4413-a9c9-d31a5c29722b (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound and the volume of distribution at steady state is approximately 100 L.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:5157767b-16d5-4a69-b6bd-95d360d19fda (opens source in a new tab)

        Ivabradine label

        Version not recorded · Effective date not recorded

        Ivabradine is approximately 70% plasma protein bound, and the volume of distribution at steady state is approximately 100 L.
  8. Projected row 798

    Medicine slug
    ivermectin
    Compared field
    halfLife
    Comparison state
    insufficient_context
    Reason codes
    • STRUCTURED_CONTEXT_MISSING
    Documents examined
    34
    Source count
    18
    Agreement rate
    0.555556
    Recorded readings
    1. 18 hours

      Numeric value
      18
      Unit
      hours
      Source records
      10

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 10 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:014e33e7-c07d-4feb-a2cf-7cd160b1facd (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:104a5045-94b1-4022-bc49-719521f30f0d (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:4cb062d7-0597-4e92-b2f6-7129a95e9500 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:e88adfbc-e375-4fea-827e-6ec51ed6fd0a (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:ad6539f2-94de-1bc5-e053-2a95a90a4cf2 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:681888c9-af79-4b7d-ae80-c3f4f6f1effd (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:847a1dd7-d65b-4a0e-a67d-d90392059dac (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:2de5ee45-0465-4996-ac00-5bdd352b4ed7 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:c8005642-3bf0-41b9-8a53-8b933c68c073 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1fb17bc2-9192-4a0b-a3ee-fda9db035daa (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
    2. 6.5 days

      Numeric value
      Not parsed
      Unit
      Not recorded
      Source records
      8

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 8 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:b1d5b166-ab06-4ab5-b0c6-31126238118a (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155± 40 hours, range 92-238 hours) in patients receiving a once daily cutaneous application of SOOLANTRA cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of SOOLANTRA cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At ther
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6b4a7400-d34c-4947-90e6-340f7087a702 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155 hours ± 40 hours, range 92 hours to 238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electro
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:81193a2d-dc0a-4ce5-a5c1-6dfd3195c4bc (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155± 40 hours, range 92 to 238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:75973e89-a03f-48dd-8fe8-8eafc1938d09 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155 ± 40 hours, range 92-238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At t
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:39fbf2b3-cd2f-4e04-99c4-ca4390fae2bd (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155± 40 hours, range 92-238 hours) in patients receiving a once daily cutaneous application of Ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of Ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At th
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1d3e7aea-02a4-46b1-8a14-0324e4777cb4 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155 ± 40 hours, range 92-238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At t
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1061e454-d1dc-4293-b18d-9c8717fbbb40 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155 ± 40 hours, range 92-238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At t
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:de9253c3-7d66-47fe-8ad7-8c0d4ee8ebda (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        Excretion The apparent terminal half-life averaged 6.5 days (mean ± standard deviation: 155± 40 hours, range 92 to 238 hours) in patients receiving a once daily cutaneous application of ivermectin cream for 28 days. 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action The mechanism of action of ivermectin cream in treating rosacea lesions is unknown. 12.2 Pharmacodynamics Cardiac Electrophysiology At
  9. Projected row 799

    Medicine slug
    ivermectin
    Compared field
    tMax
    Comparison state
    insufficient_context
    Reason codes
    • STRUCTURED_CONTEXT_MISSING
    Documents examined
    34
    Source count
    8
    Agreement rate
    0.875
    Recorded readings
    1. 10 ± 8 hours

      Numeric value
      10
      Unit
      hours
      Source records
      7

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 7 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:b1d5b166-ab06-4ab5-b0c6-31126238118a (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 - 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69-75.16 ng.hr/mL).
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:81193a2d-dc0a-4ce5-a5c1-6dfd3195c4bc (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation) plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 to 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69 to 75.16 ng•hr/mL).
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:75973e89-a03f-48dd-8fe8-8eafc1938d09 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 - 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69-75.16 ng.hr/mL).
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:39fbf2b3-cd2f-4e04-99c4-ca4390fae2bd (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 - 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69-75.16 ng.hr/mL).
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1d3e7aea-02a4-46b1-8a14-0324e4777cb4 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 - 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69-75.16 ng.hr/mL).
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1061e454-d1dc-4293-b18d-9c8717fbbb40 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 - 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69-75.16 ng.hr/mL).
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:de9253c3-7d66-47fe-8ad7-8c0d4ee8ebda (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation) plasma concentrations of ivermectin peaked (T max ) at 10 ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ± 1.04 ng/mL (range: 0.69 to 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ± 15.56 ng.hr/mL (range: 13.69 to 75.16 ng•hr/mL).
    2. 10 hours

      Numeric value
      10
      Unit
      hours
      Source records
      1

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 1 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6b4a7400-d34c-4947-90e6-340f7087a702 (opens source in a new tab)

        Ivermectin label

        Version not recorded · Effective date not recorded

        At steady state (after 2 weeks of treatment), the highest mean ± standard deviation) plasma concentrations of ivermectin peaked (T max ) at 10 hours ± 8 hours post-dose, the maximum concentration (C max ) was 2.10 ng/mL ± 1.04 ng/mL (range: 0.69 ng/mL to 4.02 ng/mL) and the area under the concentration curve (AUC 0-24hr ) was 36.14 ng.hr/mL ± 15.56 ng.hr/mL (range: 13.69 ng.hr/mL to 75.16 ng.hr/mL
  10. Projected row 800

    Medicine slug
    ketoconazole
    Compared field
    bioavailability
    Comparison state
    agree
    Reason codes
    • COMPATIBLE_VALUES_OVERLAP
    Documents examined
    59
    Source count
    12
    Agreement rate
    1
    Recorded readings
    1. 65%

      Numeric value
      65
      Unit
      %
      Source records
      12

      Population and context: Unknown: population and formulation context were not structurally extracted from this source sentence.

      Show all 12 source records
      1. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:1d598696-c6f3-4b7c-ad73-949d2089df35 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      2. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:3ea8a22b-cd61-4623-a11f-43e3396b50fa (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      3. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:f5dc1e67-639f-5476-e053-2995a90a4210 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      4. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:f162e616-21b4-49b1-b437-15e21001a6f0 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      5. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:369f31da-d3c3-49b8-956f-f70598760164 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      6. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:8ca815a8-bccb-4ee2-a042-922373329cae (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      7. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:517c29fc-2a2a-4bd5-a8bb-b464a65d2be0 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      8. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:6d4be760-c723-4f54-a854-12c61cf91703 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      9. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:57e81e13-b395-4dbd-b660-3038de41a838 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      10. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:bc189ce2-3f10-260d-e053-2a95a90ae808 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      11. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:a9fc4618-4d87-47ef-ab3c-c9ffac3ba9b7 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.
      12. FDA_LABELRetrieved 2026-08-30
        FDA_LABEL:4baebcab-a237-42c0-9183-6f447a44e371 (opens source in a new tab)

        Ketoconazole label

        Version not recorded · Effective date not recorded

        When ketoconazole was administered with non-diet cola after pretreatment with omeprazole, the bioavailability was 65% of that after administration of ketoconazole alone.

Access

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Allowed query parameters

q
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state
Exact comparability state.Values: agree, differ, not_comparable, insufficient_context
field
Exact recorded field key.Values: bioavailability, halfLife, proteinBinding, tMax, volumeOfDistribution
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